The Effect of Profen and Vitamin C on rate of Sperm abnormalties and Weight of Testes and Prostate Gland of Male White Mice

Abstract

The present research was conducted on 36 white mice of similar weights by using one of the non-
steroid anti-inflammation drugs, namely profen. Vitamin C was used to assess the sperm abnormality; the
testes mean weight, and prostate gland weight. The mice were divided into three equal groups. The mice
of the first group were injected with profen (200mg. /kg. for each), the second was injected with profen and
vitamin C (200mg. /kg. for each), and the third group was the control one. The mice of the first two groups
were injected, in the peritoneum membrane once a day for a month.
The treatment with profen resulted into an increase in the percentage of the abnormal sperms compared
to the control group (10.74 ± 1.92 and 4.17 ± 1.26 respectively). The results have shown that the treatment
with vitamin C and profen led to a decrease in the percentage of the abnormal sperms compared to the
profen group (10.74 ± 1.92). The statistical analysis has shown considerable differences (P< 0.05) for this
group compared to the control one; this means that the use of vitamin C with profen decreases the
percentage of abnormality effected by profen. Also, there happened a considerable decrease (P< 0.05) in
the testes weight treated with profen (2526.8 ± 6.48 mg.) compared to the control group (3203 ± 9.9 mg.).
However, the testes weight was high in the group treated with profen and vitamin C (3245.5 ± 13.8 mg.)
compared to the profen group. In addition, there were no considerable statistical differences between the
control group and the profen and vitamin C group.
As for the prostate gland, there was a considerable decrease (P<0.05) in the weight when treated with
profen (890 ± 9.3 mg.) compared to the control group (896 ± 9.9 mg.). Furthermore, there were no
statistically considerable differences (P< 0.05) between the profen and vitamin C group (900 ± 9.0 mg.)
compared to the control and profen groups