Synthesis, characterization and in vitro biological studies of novel Nitrilo derivatives of N-substituted phenyl piperazine

  • Idries AL-Mashkor Department of Biochemistry - College of Medicine - University of Thi-qar

Abstract

Nitrilo derivatives of N-alkyl and N-aryl phenyl piperazine have been synthesized and
screened for antibacterial and antifungal activities. All the synthesized compounds showed the
antibacterial activity against pathogenic strains of Staphylococcus aureus (MTCCB 737),
Pseudomonas aeruginosa (MTCCB 741),Streptomyces epidermidis (MTCCB 1824) and
Escherichia coli(MTCCB 1652) and antifungal activity against pathogenic strains of
Aspergillus fumigatus (ITCC 4517), Aspergillus flavus (ITCC 5192) and Aspergillus niger
(ITCC 5405). All compounds showed mild to moderate antimicrobial activity. However,
compounds 3c, 4a and 6 showed potent antibacterial activity against pathogenic strains used
in the study. Compounds 3a, 3b, 4b, and 4d showed mild to moderate antifungal activity
against Aspergillus pathogenic strains.

Published
2019-05-13
How to Cite
AL-Mashkor , I. (2019). Synthesis, characterization and in vitro biological studies of novel Nitrilo derivatives of N-substituted phenyl piperazine . University of Thi-Qar Journal of Science, 3(1), 99-106. Retrieved from https://jsci.utq.edu.iq/index.php/main/article/view/214
Section
Articles