Effect of some medicine cancer Cytotoxic Drugs on virulent bacteria E. coli injected in laboratory rats
AbstractIsolates of E. coli were exposed to sub-minimal inhibitory concentration of
each of the cytotoxic drugs MTX, 6-MP, VCR for 4 weeks . Aliquots of 0.5 ml
containing 5 x 106 CFU were injected in the peritoneal cavity of Balb/C mice .
Results revealed that the bacteria exposed to either MTX & 6-MP were more
virulent than those exposed to VCR or those not exposed to any cytotoxic drug .
After one hour from injection, the mice demonstrated bacteremia at a ratio of
5/5 then died within 3 days; histopathological examination revealed signs of
acute inflammation. Mice injected with bacterial suspension exposed to VCR,
have demonstrated symptoms after 3 hours of injection and bacteremia was
demonstrated by the ratio of 2/5 and the animals died subsequently, whereas no
infection was recorded in mice injected with bacterial suspension not exposed to
the cytotoxic drugs and all remained alive.
How to Cite
Tawfiq Al-Hadithi, H., & Abdul Redda Abbas , Y. (2019). Effect of some medicine cancer Cytotoxic Drugs on virulent bacteria E. coli injected in laboratory rats. University of Thi-Qar Journal of Science, 1(1), 9-17. Retrieved from https://jsci.utq.edu.iq/index.php/main/article/view/185