A review Study of The Chemical Constituents and Pharmacological Activities of Alstonia scholaris linn


  • Alyaa Majid University of Thi-Qar- College of Science- Department of Chemistry
  • Hadeel Rashid Faraj Department of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, 64001, Iraq.




Alstonia scholaris, Apocynaceae, Phytochemistry, Pharmacology, Alkaloids.


The Indian medical systems hold promise for the genus Alstonia. Different types of Alstonia, primarily Alstonia scholaris, have been used by the various ethnic communities in India to treat various human illnesses. A historically significant medicinal herb is Alstonia scholaris. The Indian subcontinent and Southeast Asian nations are the native habitats of this evergreen tree. The plant is used in conventional, Ayurveda, Unani, homoeopathic, Sidhha/Tamil, and other alternative medical systems to treat a variety of illnesses, including asthma, malaria, fever, dysentery, diarrhea, epilepsy, skin conditions, and snakebites, among others. Alkaloids make up the majority of reported phytochemicals. In this review, reports on pharmacological and phytochemical varieties of A. scholaris are compiled.

Author Biography

  • Hadeel Rashid Faraj, Department of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, 64001, Iraq.



III. References

D. Bandawane, A. Juvekar A, and M. Juvekar, " Antidiabetic and Antihyperlipidemic Effect of Alstonia scholaris Linn Bark in Streptozotocin Induced Diabetic Rats," Indian Journal of Pharmaceutical Education and Research, vol.45, pp. 114-120, 2011.

A. A. Herrera, A. O. Dee, and L. A. Ipulan, "Detection of congenital anomalies in Mus musculus induced by crude leaf extracts of Goniothalamus amuyon (Blanco) Merr. and Alstonia macrophylla Wall. ex G. Don, " J. Med. Plants Res, vol. 4,pp. 327–334, 2010.

S. Chaudhary, and R. Kumar, "Some important Medicinal trees of district Bijnor, "Recent Res. Sci. Technol, vol. 3, pp.96–100, 2011.

A. Majid, "Panax ginseng – A review, " University of Thi-Qar Journal Of Science, vol. 7, pp. 96-102, 2019.

J. Parekh, and S. V. Chand, "In vitro Antimicrobial Activity and Phytochemical Analysis of Some Indian Medicinal Plants, " Turk J Biol, vol.31, pp. 53-58, 2007.

H. M. Kredy, A. K. Zaid, S. S. Affat, and A. Majid, " Identification major phenolic compounds in leaves of Populus euphratica, " Basic Research Journal of Agricultural Science and Review, Vol. 4, pp. 071-074, 2015.

R. N. Okigbo, C. L. Anuagasi, J. E. Amadi, and U. J. Ukapabi, " Potential Inhibitory Effect of Some African Tuberous Plant Extracts on Escherichia Coli, Staphylococcus Aureus and Candida Albicans, " International Journal of Interactive Biology, vol. 6, pp. 91–98, 2009.

A. Majid, M. A. Auda, K. G. Al-Fartosi, " Using polyphenolic extract for tubers Cyperus rotundus to prevent myocardial infarction, " Journal of Education for Pure Science- University of Thi-Qar, Vol.11, pp. 34-41, 2021.

K. R. Kirtikar, and B. D. Basu, Indian Medicinal Plants, Vol. II, Bhushen Singh and Mahendra Pal Singh, Dehradun, pp. 111-14, 1980.

K. Pankti, G. Payal, Ch. Manodeep, K. Jagadish, " A Phytopharmacological review on Alstonia scholaris: A panoramic herbal medicine, "International Journal of Research and Ayurveda Pharmacy, vol. 3. pp. 367-371, 2012.

S. Sutha, V. Kalpana Devi, V.R. Mohan, "GC-MS determination of bioactive components of Alstonia venenata R.Br, " Research Journal of Pharmaceutical, Biological and Chemical sciences, vol. 3,pp. 291-296, 2012.

K, Pratyush, Ch. S. Misra, J. James, M.S. Lipin Dev , A. K. Veettil, V. Thankamani, " Ethnobotanical and Pharmacological study of Alstonia (Apocynaceae)- A review, " Journal of Pharmaceutical Sciences and Research, vol. 3, pp. 1394-1403, 2011.

A. K. Nadkarni, and K. M, " Nadkarni’sIndian Materia Medica," Popular Prakashan, Bombay, vol. 1, pp. 80-83, 1976

V. N. Naik, "Flora of Marathwada, " Vol. I. Amrut Prakashan, Aurangabad (MS), India, vol. 1, pp. 528–529, 1988.

Anonymous, 1985 "The Wealth of India, " Publications and information Directorate, Council of Scientific and Industrial Research, New Delhi, pp. 201–204, 1985.

T. R. Govindachari, N. Viswanathan, B. R. Pai, T. S. Savitri, "Chemical constituents of Alstonia venenata R.Br, " Tetrahedron, vol. 21, pp. 2951-6, 1965.

P. Versha, B. Ghosh, B. Anroop, and M. Ramanjit, " Antimicrobial activity of Alstonia scholaris leaf extracts, " Indian drugs, vol. 40, pp.412-13, 2003.

The Wealth of India, Raw Materials, , CSIR, New Delhi, Vol. 1, pp. 50 – 51, 2004.

A.K. Nadkarni, and K.M. Nadkarni’s, "Indian Materia Medica, " Popular Prakashan, Bombay, vol. 1, pp. 80-83, 1976.

P. S. Thomas, A. Kanaujia, D. Ghosh, R. Duggar, and C. K. Katiyar, " Alstonoside, a secoiridoid glucoside from Alstonia scholaris, " Indian J. Chem. B Org, vol. 47, pp. 1298-1320, 2008 2008.

D. N. Guhabakshi, P. Sensarma, and D. C. Pal, " A Lexicon of Medicinal Plant in India," Naya Prakash, Calcutta, vol. 2, 1999

M. S. Khyade, and N. P. Vaikos, " Pharmacognostical studies on the leaves of Alstonia scholaris R. Br, " J. Pharm. Res, vol. 2, pp. 858–861, 2009.

R. S. Gupta, R. Sharma, A. Sharma, A. K. Bhatnager, M. P. Dobhal, Y. C. Joshi, and M. C. Sharma, " Effect of Alstonia scholaris bark extract on testicular function of Wistar rats, " Asian J. Androl, vol. 4, pp. 175–178, 2002.

N. X. Dung, R. H. Ngoc, D. D. Rang, N. T. Nhan, N. Klinkby, and P. A. Leclercq, " Chemical composition of the volatile concentrate from the flowers of Vietnamese Alstonia scholaris (L.) R. Br., Apocynaceae, " J. Essent. Oil Res, vol. 13, pp. 424–426, 2001.

P. K. Singh, R. K. Kumar, Vinod, Tiwari, A. Sharma, C. V. Rao, R. H. Singh, " 2010. Medico-Ethnobotany of ‘Chatara’ block of District Sonebhadra, " Uttar Pradesh, India. Adv. Biol. Res, vol. 4, pp. 65–80, 2010.

M. Atta-Ur-Rahman, J. Asif, Ghazala, and K. A. Fatima, " Alvi. Scholaricine, an alkaloid from Alstonia scholaris, " Phytochemistry, vol. pp. 2771-73, 1985.

Atta-ur-Rahman, " Isolation, structural and synthetic studies on the chemical constituents of medicinal plants of Pakistan, " Pure and Appl. Chem, vol. 58, pp. 663-73, 1986.

Atta-ur- Rahman, A. Muzaffar, and N. Doulatabadi, " Isolation and 1H/13C-NMR studies on 19, 20-dihydrocondylocarpine – an alkaloid from the leaves of Ervatamia coronaria, " Phytochemistry, vol. 25, pp. 1781-83, 1986.

Atta-ur-Rahman, K.A. Alvi, S.A. Abbas, and W. Voelter, " Isolation of 19, 20-ZVallesamine and 19, 20 – E – Vallesamine from Alstonia scholaris, " Heterocycles, vol. 26, pp. 413-419, 1987.

T. Yamauchi, F, Abe, G William, Padolina, and M. F. Dayrit, " Alkaloids from leaves and bark of Alstonia scholaris in the Philippines, " Phytochemistry, vol. pp. 3321-25, 1990.

M. Gandhi, V.K. Vinayak, 1990. " Preliminary evaluation of extracts of Alstonia scholaris bark for in vivo antimalarial activity in mice, " J. Ethnopharmacol, vol. 29, pp. 51–57, 1990.

N. Keawpradub, P. J. Houghton, " Indole alkaloids from Alstonia macrophylla, " Phytochemistry, vol. 46, pp. 757–762, 1997.

M. M. Goyal, and A. Varshney, " Effects of natural products isolated from three species of Alstonia on some gram-positive and gram-negative bacteria, " Indian Drugs, vol. 32, pp. 69-72, 1995.

M. R. Khan, A. D. Omoloso, and M. Kihara, " Antibacterial activity of Alstonia scholaris and Leea tetramera, " Fitoterpia, vol. 74, pp. 736-40, 2003.

C. Pradeep Kumar, T. Sravanthi, Dr. Vijaya Kuchana, and C. H.Maheswara Reddy, " Anti- Depressant activity of Alstonia venenata R.Br.stem bark extracts in In-vivo methods. Journal of Pharmaceutical and Biomedical Analysis Letters. 2015;3(1):218-223.

R.S. Patil, A.R. Juvekar, S.N. Joglekar, P.B. Shamkuwar and S.R. Nimbkar. Study of antidiarrhoeal activity of Alstonia scholaris bark, " Indian Drugs, vol. 36, pp. 463, 1999.

H. Sies, " Antioxidants in Disease, Mechanisms and Therapy, Academic Press, New York, 1996.

D. M. Kasote, 2013 " Flaxseed phenolics as natural antioxidants: a review, " Int. Food Res. J, vol. 20, pp. 1797–1804, 2013.

A. Kumar, R. Kaur, and S. Arora, 2010 " Free radical scavenging potential of some Indian medicinal plants, " J. Med. Plants Res, vol. 4, pp. 2034–2042, 2010.

J. James, A. K. Thaliyil Veettil, P. Kumar, C. S. Misra, M. S. Lipin Dev, ad V. Thankamani, V, " 2011 In vitro antioxidant activity of flowers and fruits of Alstonia scholaris, " Int. J. Phytomed, vol. 3,pp. 475–479, 2011.

N. Keawpradub, P. J. Houghton, E. Eno-Amooquaye, and P.J. Burke, " Activity of extracts and alkaloids of thai Alstonia species against human lung cancer cell lines, "

Planta Med, vol.63, pp. 97-101, 1997.

K. Thomas, M. Kunjumon, R. E. George, ad T. Vaidyanatha Iyer, " A comparative study of antifungal activity of Alstonia venenata R.Br, " International Journal of Pharmaceutical sciences and Research, vol. 6, pp. 1741-1745, 2015.

S. Ozawa, H. Kamiya, and K. Tsuzuki, "Glutamate receptors in the mammalian central nervous system, " Prog. Neurobiol, vol. 54, pp. 581 – 618, 1998.

D. Chattopadhyay, G. Arunachalam, L. Ghosh, K. Rajendran, A. B. Mandal, and S. K. Bhattacharya, " Antipyretic activity of Alstonia macrophylla wall ex A. DC: an ethnomedicine of Andaman Islands, " J. Pharm. Pharm. Sci, vol. 8, pp. 558–564, 2005.

S.C. Lin, C.C. Lin, Y.H. Lin, S. Supriyatna S, and S. L. Pan, " The protective effect of Alstonia scholaris R.Br. on hepatotoxin-induced acute liver damage, " Am. J. Clin. Med, vol. 24, pp.153-64, 1996.

R.S. Gupta, A.K. Bhatnager, Y.C. Joshi, M.C. Sharma, V. Khushalani, and J.B. Kacchawa, " Induction of antifertility with lupeol acetate in male albino rats, " Pharmacology, vol. 75, pp. 57 – 62, 2005.

U. Gupta, R. Chaudhary, and P. K. Goyal, " 2010. Post-treatment effects of Alstonia scholaris extract against radiation-induced biochemical alterations in Swiss albino mice, " Iran. J. Radiat. Res, vol. 8, pp. 169–177, 2010.

D. Chattopadhyay, G. Arunachalam, L. Ghosh, and A. B. Mandal, " 2004. CNS activity of Alstonia macrophylla leaf extracts: an ethnomedicine of Onge of Bay Islands, " Fitoterapia, vol. 75, pp. 673–682, 2004.

M. D. R. Camacho, J. D. Phillipson, S. L/ Croft, P. N. Solis, S. J. Marshall, and S. A. Ghazanfar, " 2003. Screening of plant extracts for antiprotozoal and cytotoxic activities, " J. Ethnopharmacol, vol. 89, pp. 185–191, 2003.

I. I. Maria II, A. S. Andreanus , S. R. Debbie, Un. Mu. Sukrasno, " Immnunosimilating effect of ,Pule , (Alstonia scholaris L.R. Br, Apocynaceae) bark extracts., " Clin Hemorheaol Micro, vol. 23, pp. 177-83. 2000,








How to Cite

A review Study of The Chemical Constituents and Pharmacological Activities of Alstonia scholaris linn. (2023). University of Thi-Qar Journal of Science, 10(1), 81-86. https://doi.org/10.32792/utq/utjsci/v10i1.934