The Prevalence of blaCTX-M, blaTEM Genes in Bacteria Isolated From Bladder Cancer Patients with Urinary Tract Infections

Abstract

Urinary tract infections (UTIs) are among the most prevalent infections in cancer patients . Two hundred urine samples were taken from patients with bladder cancer between the dates of 1 April 2021 and 15 October 2021 while they were enrolled in third floor Ghazi Al- Hariri Hospital, Medical City, Baghdad Province, and private clinics in Nasiriyah Province (100 from patients treated with MMC and 100 from patients treated with BCG). Forty urine samples were taken from patients with UTI without Bladder Ca (control). The most commonly pathogens were Escherichia coli  , followed by Klebsiella pneumoniae  , Pseudomonas     aeruginosa  and Staphyllococcus aureus  and other genera of UTI bacterium. The total ESBLs Producers in the current study from 40 isolates was (27)72.5%.The highest ESBLs Producer    in all Groups was E.coli  followed by K.pneumoniae and P.aeruginosae  . According to PCR out of 38 Clinical specimen from all groups , results of the bla _CTX-M gene indicated its presence in 21 isolate(55.2%),while the presence of  bla _TEM gene was  26(68.4%) of total isolates.