Evaluation of Bone Resorption in Type I diabetes Mellitus Patients by Measuring Urinary Total Deoxypyridinoline ( U. DPD) as a Biomarker of Bone Resorption

Abstract

Background: Diabetes mellitus is a common disease in most parts of the world, the metabolic abnormalities of diabetes potentially affect bone metabolism, structure, mineral density, and bone resorption, as part of physiological bone turnover. Aim: This study aimed to estimate urinary total deoxypyridinoline as a biomarker of mature bone collagen degradation and bone resorption in type I diabetes mellitus patients and evaluate its relationship with fasting blood sugar, serum bone minerals profile and the duration of disease and also to investigate  the degree of severity of bone resorption and the probability of  fracture risk. Patients and methods:165patients with type I diabetes mellitus from Diabetes mellitus and Endocrine Disease Centre at AL -Nasiriyah city in Thi-Qar province, Iraq were studied.100 (60.6%) were female and 65(39.4%) were male, age was between(25-65) year, mean44.27±11.1,their duration with type 1 DM disease ranged from 5 months to 10 years, they were classified into three groups: the first group included 45 (27.3 %)  patient their duration with type 1 DM  were  less than one year, the second group included 65 (39.4%) their duration with type I DM were 1 to 5 year and the third group included 55 (33.3%) patient their duration with disease were from 6 to 10 year. Fasting blood venous and first-morning urine samples were collected for biochemical investigation according to standard methods and Urine DPD was measured by the quantitative competitive enzyme immunoassay. Also, this study included 165 normal people selected as a control group.