Synthesis, characterization and evaluation biological activity of new Schiff base compounds and their complexes with some transition elements

Abstract

The novel Schiff base ligand L₁ (Z)-N'-(2-hydroxy-3-methoxybenzylidene)isonicotinohydrazide and L₂ (Z)-N'-(2-hydroxy-3-methoxybenzylidene)nicotinohydrazide obtained by the condensation of isonicotinic hydrazide and benzahydrazide with o-Vanilin (2-hydroxy-3-methoxybenzaldehyde)  and its  Co(II), Ni(II) and Cd(II) complexes were synthesized and characterized by elemental analysis and various physico-chemical techniques like, FT-IR, ¹H-NMR, Electrospray Ionisation mass(ESI-MS), UV-visible and molar conductance. The ligand involving oxygen atom of amide carbonyl, azomethine nitrogen and oxygen of hydroxyl via deprotonation. Spectral analysis indicates octahedral geometry for all the complexes. has 2:1 stoichiometry ratio of the type[M(L₂)₂Cl]. Schiff bases ligands and their complexes has been studied the biological activity where the schiff bases L₁, L₂ and their complexes showed lower efficiency than the standard inhibitor (Cipro.) trend three types of bacteria E-coli, salmonella spp. and staph. aureus, the prepared complexes appeared high effective than the effectiveness of the Schiff bases itself