Synthesis And Characterizaition Of Biscyclic β - Lactams As Blood Cholestrol Inhibitors

  • Wisam Obaid Salman Chemistry Dept-Science College Thiqar university-Thiqar-Nashyria,Iraq
Keywords: β- LACTAMS , [2 2] CYCLOADDITION , 3-(4-CHLOROPHENYL)

Abstract

This study is concerned with the synthesis and characterization of the 3-(4-chlorophenyl) bicyclic azetidin -2-one 3a. This compound 3a was prepared by reacting 3-(4-chlorophenyl) acetic acid with the appropriate Schiff’s base 2a in the presence of triethylamine with phosphorusoxychloride in dry dichloromethane under nitrogen atmosphere at -10˚C. The active acid chloride reacts with triethylamine to generate corresponding ketene in situ which further reacts with Schiff’s base to furnish corresponding 3-(4-chloroPhenyl)bicyclic azetidin 2–ones 3a.And it was a study of the activity biological to compound 3a to inhibition of cholesterol in the blood of some laboratory animals.

Published
2019-07-05
How to Cite
Salman, W. O. (2019). Synthesis And Characterizaition Of Biscyclic β - Lactams As Blood Cholestrol Inhibitors. University of Thi-Qar Journal of Science, 4(3), 123-129. Retrieved from https://jsci.utq.edu.iq/index.php/main/article/view/643
Section
Articles