Synthesis, Characterization, Bioactivity and Cytotoxicity of NS Schiff base and its Ni (II), Cd(II) and Zn(II) metal complexes

Authors

  • Isam Hussain T. Al-Karkhi Department of Basic Science- College of Dentistry- University of Baghdad- Bab Al-Moazam- Baghdad - Iraq

Keywords:

igand, pyridine, ethanone, metal complexes

Abstract

A new nitrogen sulphur Schiff base has been prepared from the condensation 1-(pyridin-4-yl)ethanone with 2-
methylbenzyl hydrazinecarbodithioate. The ligand was reacted with Ni(II), Cd(II) and Zn(II) metal salts to form new
coordinated complexes. The new 2-methylbenzyl (2Z)-2-[1-(pyridin-4-yl)ethylidene]hydrazinecarbodithioate ligand and
the new metal complexes were characterized via various physico-chemical and spectroscopic techniques and based on
the data analysis the metal complexes are expected to be octahedral in geometry. The Schiff bases and their complexes
were screened for antimicrobial and cytotoxic activities. [Cd(NS)2] displays strong activity against the bacteria strains
and cytotoxicity while the other compounds shows moderate and weak activity.
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Published

2019-07-04

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Articles

How to Cite

Synthesis, Characterization, Bioactivity and Cytotoxicity of NS Schiff base and its Ni (II), Cd(II) and Zn(II) metal complexes. (2019). University of Thi-Qar Journal of Science, 4(2), 52-58. https://jsci.utq.edu.iq/index.php/main/article/view/594