The association among vitamin D and lipids in Pediatric Population with type 1 diabetes
DOI:
https://doi.org/10.32792/utq/utjsci/v13i1.1576Abstract
In pediatric populations with Type 1 Diabetes Mellitus (T1DM), an autoimmune condition brought on by the destruction of pancreatic β-cells and a complete lack of insulin, vitamin D deficiency is a serious problem. The aim of the study is to investigate the prevalence of vitamin D deficiency among Iraqi pediatric patients and healthy individuals (all aged between 4 and 18 years).The study involved 80 pediatric patients with T1DM and 40 individuals healthy ,among the biochemical markers examined it Vitamin D levels and lipid functions involved total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL) and high-density lipoprotein (HDL) also measure fasting blood glucose (FBS), and glycated hemoglobin (HbA1c).After examining the results, following analysis of the data, it was discovered to rise with a highly significant difference (p ≤ 0.001) of the TC, LDL, FBS, and HbA1c levels as compared to the healthy group. The results also revealed decreased serum levels of HDL and vitamin D3, with a very significant difference (p ≤ 0.001). In contrast, levels were high both TG and VLDL with a significant difference (p <0.05). The study found the patients have a relatively high rate of vitamin D deficiency, therefore, early childhood is the optimal time to begin screening and treatment for vitamin D deficiency
Received: 25-02-2026
Revised: 29-04-2026
Accepted: 12-05-2026
References
A. Chadt and H. J. P. A.-E. J. o. P. Al-Hasani, "Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease," Pflügers Archiv-European Journal of Physiology, vol. 472, no. 9, pp. 1273-1298, 2020.
M. R. Alkubaisi, A. S. Lateef, A. D. Salman, N. T. Tahir, and A. R. J. a. Al-Abdaly, "Estimation of Prolactin Level in Iraqi Diabetic Women of Menopause," Atherosclerosis, vol. 17, no. 2, pp. 165-171, 2023.
A. Arafat et al., "Glucagon increases circulating fibroblast growth factor 21 independently of endogenous insulin levels: a novel mechanism of glucagon-stimulated lipolysis?," Diabetologia, vol. 56, no. 3, pp. 588-597, 2013.
G. Muscogiuri et al., "Mechanisms in endocrinology: vitamin D as a potential contributor in endocrine health and disease," The European Journal of Endocrinology, vol. 171, no. 3, pp. R101-R110, 2014.
J. Tuomilehto, G. D. Ogle, N. A. Lund-Blix, and L. C. J. P. e. r. P. Stene, "Update on Worldwide Trends in Occurrence of Childhood Type 1 Diabetes in 2020," Pediatric Endocrinology Reviews: PER, vol. 17, no. Suppl 1, pp. 198-209, 2020.
Q. Mansi and A. J. P. J. M. H. S. Aziz, "Comparative study between diabetes mellitus and nondiabetic mellitus toward vitamin D deficiency in children under five year," Pakistan Journal of Medical and Health Sciences, vol. 15, pp. 818-22, 2021.
E. Mihoubi et al., "Metabolic imbalance and vitamin D deficiency in type 1 diabetes in the Algerian population," Endocrine, Metabolic & Immune Disorders - Drug Targets, vol. 19, no. 8, pp. 1172-1176, 2019.
J. S. Adams, M. J. T. J. o. C. E. Hewison, and Metabolism, "Update in vitamin D," The Journal of Clinical Endocrinology & Metabolism, vol. 95, no. 2, pp. 471-478, 2010.
A. Zittermann, S. J. S. Prokop, Vitamin D, and S. Cancer, "The role of vitamin D for cardiovascular disease and overall mortality," Springer Nature, pp. 106-119, 2015.
C. S. Zipitis and A. K. J. A. o. d. i. c. Akobeng, "Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis," Archives of disease in childhood, vol. 93, no. 6, pp. 512-517, 2008.
E. J. E. P. Barengolts, "Vitamin D and prebiotics may benefit the intestinal microbacteria and improve glucose homeostasis in prediabetes and type 2 diabetes," Endocrine Practice, vol. 19, no. 3, pp. 497-510, 2013.
D. D. Salman, "Covid 19 Infection," International Journal for Research in Applied Sciences and Biotechnology, vol. 8, pp. 140-137, 2021.
B. Billaudel, L. Barakat, A. J. D. Faure-Dussert, and metabolism, "Vitamin D3 deficiency and alterations of glucose metabolism in rat endocrine pancreas," Diabetes & Metabolism, vol. 24, no. 4, pp. 344-350, 1998.
I. Sergeev and W. J. E. Rhoten, "1, 25-Dihydroxyvitamin D3 evokes oscillations of intracellular calcium in a pancreatic beta-cell line," Endocrinology, vol. 136, no. 7, pp. 2852-2861, 1995.
I. Syed et al., "PAHSAs attenuate immune responses and promote β cell survival in autoimmune diabetic mice," The Journal of Clinical Investigation, vol. 129, no. 9, pp. 3717-3731, 2019.
W. Sun et al., "Lipid metabolism: immune regulation and therapeutic prospectives in systemic lupus erythematosus," Frontiers in Immunology, vol. 13, p. 860586, 2022.
K. Herzog et al., "Alterations in biomarkers related to glycemia, lipid metabolism, and inflammation up to 20 years before diagnosis of type 1 diabetes in adults: findings from the AMORIS cohort," Diabetes Care, vol. 45, no. 2, pp. 330-338, 2022.
D. La Torre et al., "Decreased cord-blood phospholipids in young age–at–onset type 1 diabetes," Diabetes, vol. 62, no. 11, pp. 3951-3956, 2013.
K. C. Donaghue et al., "Microvascular and macrovascular complications in children and adolescents," Pediatric Diabetes, vol. 15, 2014.
A. D. Salman and M. J. J. A. o. t. R. S. f. C. B. Al-Shammaa, "Effect of Osteopontin and Other Biochemical Markers on Iraqi Women with Osteoporosis," Annals Of The Romanian Society For Cell Biology, vol. 25, no. 3, pp. 2264-2268, 2021.
A. Vargas-Vázquez et al., "Comparative assessment of LDL-C and VLDL-C estimation in familial combined hyperlipidemia using Sampson’s, Martin’s and Friedewald’s equations," Lipids in Health and Disease, vol. 20, no. 1, p. 46, 2021.
S. Savastio et al., "Vitamin D deficiency and glycemic status in children and adolescents with type 1 diabetes mellitus," Plosone, vol. 11, no. 9, p. e0162554, 2016.
D. Gülcü Taşkın, H. Onal, A. Ersen, and E. J. C. M. Adal, "Significant vitamin D deficiency in children ID and adolescents with type 1 diabetes mellitus: a cross-sectional study," Comprehensive Medicine, vol. 12, no. 3, pp. 217-221, 2020.
L.-P. He, Y.-X. Song, T. Zhu, W. Gu, and C.-W. J. J. o. D. R. Liu, "Progress in the relationship between vitamin D deficiency and the incidence of type 1 diabetes mellitus in children," Journal of Diabetes Research, vol. 2022, no. 1, p. 5953562, 2022.
X. Yang, H. Jiang, M. Liao, M. Lin, and J. J. F. i. P. Wu, "Construction of a nomogram for predicting serum vitamin D deficiency in children/adolescents with new-onset type 1 diabetes: a single-center study in China," Frontiers in Pediatrics, vol. 13, p. 1554833, 2025.
M. M. Mendes, K. H. Hart, E. L. Williams, J. Mendis, S. A. Lanham-New, and P. B. J. T. J. o. n. Botelho, "Vitamin D supplementation and sunlight exposure on serum vitamin D concentrations in 2 parallel, double-blind, randomized, placebo-controlled trials," The Journal of Nutrition, vol. 151, no. 10, pp. 3137-3150, 2021.
C. Tully, L. Aronow, E. Mackey, and R. J. C. d. r. Streisand, "Physical activity in youth with type 1 diabetes: a review," Current Diabetes Reports, vol. 16, no. 9, p. 85, 2016.
J. A. Pivovarov, C. E. Taplin, and M. C. J. P. d. Riddell, "Current perspectives on physical activity and exercise for youth with diabetes," Pediatric Diabetes, vol. 16, no. 4, pp. 242-255, 2015.
S. F. Al-Saadi, M. A. Al-Nuaimi, and S. M. J. I. j. o. I. T. Al-Maamouri, "Dyslipidemia among Diabetic Children in Baghdad," International journal of Information Technology, vol. 40, pp. 500-511, 2021.
G. D. Zambrana-Calví, E. Palomo-Atance, M. E. Gourdet, A. León-Martín, M. J. Ballester-Herrera, and P. J. E. y. N. Giralt-Muiña, "Lipid changes and their relationship with vitamin D levels in children under 18 years with type 1 diabetes," Endocrinología y Nutrición, vol. 63, no. 3, pp. 126-131, 2016.
H. Soliman and A. J. E. P. A. G. Ibrahim, "Prevalence and pattern of dyslipidemia in an Egyptian children and adolescents with type 1 diabetes," Egyptian Pediatric Association Gazette, vol. 69, no. 1, p. 21, 2021.
D. Guggisberg et al., "Molecular effects of the consumption of margarine and butter varying in trans fat composition: a parallel human intervention study," Lipids in Health and Disease, vol. 21, no. 1, p. 74, 2022.
R. Nufer et al., "International Society for Pediatric and Adolescent Diabetes," Hormone Research, vol. 50, pp. 107-140, 1998.
H. Alasbily, S. Abdalrahman, M. Netfa, A. Elemmami, A. J. A. J. o. M. Aldebani, and A. Sciences, "The association between vitamin D status and glycemic control in children and adolescents with type 1 diabetes," AlQalam Journal of Medical and Applied Sciences, pp. 470-476, 2024.
A. L. Monteiro et al., "Lipid profile of children and adolescents with type 1 diabetes mellitus," Soc. Bras. Pediatr, vol. 170, pp. 170-199, 2020.
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