Integrated Effects of Vitamins B6 and C with Selected Minerals in Enhancing Immunomodulatory and Reducing Obesity Risk in Rats
DOI:
https://doi.org/10.32792/utq/utjsci/v13i1.1539Keywords:
Immune Modulation, Vitamins, Minerals, Lipid Profile, RatsAbstract
Abstract: The study aimed to assess the impacts of vitamins (C, B6) and minerals (magnesium, calcium, and zinc) on pathways of immunoglobulins (IgA, IgM, IgE, IgD, and IgG), cytokines (IL-10, IL-12, LEP, ADP and TNF- α), lipid profile (S.CH, S.TG, LDL, HDL and V.LDL), and the body weight in standard diet and high-fat diet rat models. Sixty male albino rats were designated into two groups (S.D = 30 rats) and (H.F = 30 rats) during the period from October 2024 to May 2025. ELISA was used to detect immunoglobulins and cytokines; lipid profile was estimated by (Cobas C111) and body weight was measured by lab balance. IgA was non-significant in both groups. IgM in both groups was not significant. IgD was significant (p<0.05) in standard diet group but was non-significant in high-fat diet group. The variations in both groups for IgE and IgG were not remarkable. IL-10 was significant (p<0.05) in S.D group but not in H.F.D group while IL-12 and TNF-α were not significant in neither groups. Adiponectin was significant (p<0.05) in both groups. Leptin was non-significant in S.D group but was significant (p<0.05) in the H.F.D group. Cholesterol was reported to be significant (p<0.05) in both groups while TG was only significant (p<0.05) in S.D group. LDL and HDL were significant (p<0.05) in both groups.
Received: 28-12-2025
Revised: 14-02-2026
Accepted: 11-03-2026
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