Female Reproductive Tract Infections in Married Women: A Review Study
DOI:
https://doi.org/10.32792/utq/utjsci/v13i1.1521Keywords:
married women , reproductive tract infectionsAbstract
Female reproductive tract infections (FTIs) are common issues among women in general, negatively affecting reproductive health, and are more widespread among married women. Therefore, this review aimed to identify the types and causes of FTIs in married women. It demonstrated the prevalence of various kinds of female reproductive tract infections among married women, especially during pregnancy, which can be transmitted to the fetus during pregnancy or childbirth. These infections include fungal, bacterial, and sexually transmitted infections, which are transmitted sexually, caused by multiple factors and risk elements such as unhealthy sexual behaviors, poor hygiene, social influences, weakened immunity, frequent use of medications, and certain types of contraceptives. Female sex hormones also significantly influence the development of infection by impacting behavioral, immunological, and physiological parameters in affected women. Consequently, understanding these factors is essential for developing effective infection prevention strategies. The widespread prevalence of female reproductive tract infections (FTIs) calls for a comprehensive approach to assessing the health risks to both mother and child.
Received: 25-11-2025
Revised: 26-12-2025
Accepted: 02-01-2026
References
[1] R. C. Brunham and J. Paavonen, “Reproductive system infections in women: lower genital tract syndromes,” Pathogens and Disease, vol. 78, no. 5, Jul. 2020, p. ftaa02. doi: 10.1093/femspd/ftaa022
[2] S. Xu, C. Yu, Y. Zhou, J. Wu, T. Bai, J. Zhang, and Y. Li, “The prevalence of reproductive tract infections in a Chinese internal migrant population, and its correlation with knowledge, attitude, and practices: A cross-sectional study,” International Journal of Environmental Research and Public Health, vol. 16, no. 4, p. 655, Feb. 2019. doi: 10.3390/ijerph16040655
[3] H. Li, Y. Zang, C. Wang, H. Li, A. Fan, C. Han, and F. Xue, “The interaction between microorganisms, metabolites, and immune system in the female genital tract microenvironment,” Frontiers in Cellular and Infection Microbiology, vol. 10, Art. no. 609488, Dec. 23, 2020. doi: 10.3389/fcimb.2020.609488
[4] K. Y. Çalık, R. Erkaya, G. İnce, and N. K. Yıldız, “Genital hygiene behaviors of women and their effect on vaginal infections,” Clinical and Experimental Health Sciences, vol. 10, no. 3, pp. 210–216, 2020. doi:10.33808/clinexphealthsci.565845
[5] A. Umami, E. Paulik, R. Molnár, and M. Bhisma, “The relationship between genital hygiene behaviors and genital infections among women: A systematic review,” Jurnal Ners, vol. 17, no. 1, pp. 89–101, 2022. doi. 10.20473/jn. v16i1.34402
[6] J. D. Sobel and P. Nyirjesy, “Vulvovaginitis,” in Female Sexual Pain Disorders: Evaluation and Management, pp. 227–238, Aug. 20, 2020.doi: 10.1002/9781119482598.ch28
[7] H. Mujuzi, A. Siya, and R. Wambi, “Infectious vaginitis among women seeking reproductive health services at a sexual and reproductive health facility in Kampala, Uganda,” BMC Women’s Health, vol. 23, no. 1, p. 677, Dec. 19, 2023. doi:10.1186/s12905-023-02835-w.
[8] S. M. Saleh, M. A. Attban, and S. A. Bahr, “Vaginitis in Iraqi women through a cross-sectional study of 90 patients,” Journal of Medical Sciences, vol. 3, no. 5, pp. 30–35, May 29, 2024.doi:10.5281/zenodo.11378640.
[9] S. Mehnaz, A. J. Abedi, and M. A. Ansari, “Reproductive tract infections: Prevalence and associated sociodemographic Factors among Married Women in Rural Areas of Aligarh,” Indian Journal of Public Health Research & Development, vol. 15, no. 3, Jul. 1, 2024 .doi:10.37506/xvath690.
[10] I. U. Macias-Paz, S. Pérez-Hernández, A. Tavera-Tapia, J. P. Luna-Arias, J. E. Guerra-Cárdenas, and E. Reyna-Beltrán, “Candida albicans the main opportunistic pathogenic fungus in humans,” Revista Argentina de Microbiología, vol. 55, no. 2, pp. 189–198, Apr. 1, 2023. doi: 10.1016/j.ram.2022.08.003
[11] D. Rosati, M. Bruno, M. Jaeger, J. Ten Oever, and M. G. Netea, “Recurrent vulvovaginal candidiasis: an immunological perspective,” Microorganisms, vol. 8, no. 2, p. 144, Jan. 21, 2020. doi:10.3390/microorganisms8020144.
[12] S. A. Alawfi, “Health of Saudi Women in the Post-Pandemic Era: Candidiasis Incidence and Post COVID-19 and COVID-19-Vaccination,” International Journal of Women’s Health, pp. 1687–1697, Dec. 31, 2024. doi:10.2147/IJWH.S472953.
[13] E. M. Ojen, N. O. Njok, M. Mbah, N. G. Akpan, and L. I. Ugar, “Evaluation of vulvovaginal candidiasis and susceptibility patterns of isolates among married and unmarried women of childbearing age and the associated risk factors in Calabar, Nigeria,” Sokoto Journal of Medical Laboratory Science, vol. 9, no. 2, pp. 112–120, Dec. 6, 2024. doi:10.4314/sokjmls. v9i2.15
[14] S. Kumar, A. Kumar, M. Roudbary, R. Mohammadi, L. Černáková, and C. F. Rodrigues, “Overview on the infections related to rare Candida species,” Pathogens, vol. 11, no. 9, p. 963, Aug. 24, 202. doi. 10.3390/pathogens11090963
[15] A. M. Elgobbi, “Investigations of genitourinary candida infections of patients, women attending gynecology clinic at Sirte Clinics Complex, Sirte city, Libya,” Sirte University Scientific Journal, vol. 14, no. 2, pp. 126–131, Dec. 24, 2024. doi:10.37375/susj.v14i2.3103
[16] Z. Mollazadeh-Narestan, P. Yavarikia, A. Homayouni-Rad, H. Samadi Kafil, S. Mohammad-Alizadeh-Charandabi, P. Gholizadeh, and M. Mirghafourvand, “Comparing the effect of probiotic and fluconazole on treatment and recurrence of vulvovaginal candidiasis: a triple-blinded randomized controlled trial,” Probiotics and Antimicrobial Proteins, vol. 15, no. 5, pp. 1436–1446, Oct. 2023. doi:10.1007/s12602-022-09997-3
[17] S. S. Ismael, “Prevalence of Trichomoniasis and Vulvovaginal Candidiasis Among Married Women in Duhok City, Kurdistan Region, Iraq,” Archives of Razi Institute, vol. 79, no. 2, p. 303, Apr. 30, 2024. doi: 10.32592/ARI.2024.79.2.303.
[18] S. M. Abdullah, “Prevalence of Candida spp. in women with vulvovaginal infection in Maternity Teaching Hospital in Erbil, Iraq,” Iraq Medical Journal, vol. 4, no. 1, Mar. 26, 2020.doi:10.22317/imj.v4i1.776.
[19] L. Riganelli, V. Iebba, M. Piccioni, I. Illuminati, G. Bonfiglio, B. Neroni, L. Calvo, A. Gagliardi, M. Levrero, L. Merlino, and M. Mariani, “Structural variations of vaginal and endometrial microbiota: hints on female infertility,” Frontiers in Cellular and Infection Microbiology, vol. 10, Art. no. 350, Jul. 14, 2020. doi: 10.3389/fcimb.2020.00350.
[20] M. Rajabpour, A. D. Emamie, M. R. Pourmand, N. N. Goodarzi, F. A. Asbagh, and D. M. Whiley, “Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis among women with genitourinary infection and pregnancy-related complications in Tehran: A cross-sectional study,” International Journal of STD & AIDS, vol. 31, no. 8, pp. 773–780, Jul. 2020. doi:10.1177/0956462420922462
[21] S. O. Haydar and I. Naqid, “A study of bacterial Vaginosis and associated risk factors among married women in Zakho city, Kurdistan region, Iraq,” Journal of Life and Bio Sciences Research, vol. 3, no. 2, pp. 33–39, Aug. 17, 2022. doi.org/10.38094/jlbsr30262
[22] S. M. Mohammed-Amin, B. M. Jaralla, K. M. Ali, and H. Tawfeeq, “Prevalence of bacterial vaginosis among Married Women in Kalar District, Iraqi Kurdistan Region,” Passer Journal of Basic and Applied Sciences, vol. 3, no. 2, pp. 194–199, Sep. 1, 2021. doi: 10.24271/PSR.32.
[23] S. Mohammad, A. Mohsen, and I. Jalil, “Assessing the prevalence of bacterial vaginosis among infertile women in Thi-Qar Province, Iraq,” Infection Epidemiology and Microbiology, vol. 10, no. 4, Dec. 10, 2024. doi: 10.61186/iem.10.4.287.
[24] T. Zhao, X. Xiao, L. Xiao, X. M. Wu, and T. Yuan, “Bacterial vaginosis, vulvovaginal candidiasis, and trichomonal vaginitis in reproductive-age women in Yunnan, China: a descriptive study,” Journal of Obstetrics and Gynaecology, vol. 42, no. 7, pp. 3187–3192, Oct. 3, 2022. doi:10.1080/01443615.2022.2109134.
[25] I. J. Nkwoka and O. C. Eneh, “Prevalence and factors associated with bacterial vaginosis among women of reproductive age attending General Hospitals in Sokoto State, Nigeria,” International Archives of Medical and Health Research, vol. 4, no. 1, pp. 29–35, 2023.doi:10.33515/iamhr/2023.012/04
[26] F. T. Zahra, U. F. Sultana, and N. Quinn-Walker, “Overview of menstrual hygiene management and other risk factors concerning bacterial vaginosis,” Discover Public Health, vol. 22, no. 1, p.1-0, 2025. doi:10.1186/s12982-025-00416-w.
[27] O. T. Van Gerwen, C. A. Muzny, and J. M. Marrazzo, “Sexually transmitted infections and female reproductive health,” Nature Microbiology, vol. 7, no. 8, pp. 1116–1126, Aug. 2022. doi:10.1038/s41564-022-01177-x
[28] J. Paul, “Urinary and genital tract infections,” in Disease Causing Microbes, Cham: Springer International Publishing, pp. 217–246, Jan. 3, 2024. doi:10.1007/978-3-031-28567-7_5
[29] T. Garg and A. Maheshwari, “Sexually transmitted diseases in females,” in Skin Diseases in Females, Singapore: Springer Nature Singapore, pp. 413–448, Nov. 12, 2022. doi:10.1007/978-981-16-6065-8_18
[30] E. A. El-Moselhy, L. Issa, M. Mohamed, M. Abdelati, R. Eldhshan, A. Mekky, H. Amin, M. Bashir, B. Badr, and A. Al Saadawy, “Sexually transmitted infections: risk-factors among married female patients in Assiut, Egypt,” Al-Azhar International Medical Journal, vol. 1, no. 10, pp. 62–71, Oct. 1, 2020. doi:10.21608/aimj.2020.38500.1295.
[31] N. Alomair, S. Alageel, N. Davies, and J. V. Bailey, “Sexually transmitted infection knowledge and attitudes among Muslim women worldwide: a systematic review,” Sexual and Reproductive Health Matters, vol. 28, no. 1, p. 1731296, Jan. 1, 2020.doi:10.1080/26410397.2020.1731296
[32] N. Alomair, S. Alageel, N. Davies, and J. V. Bailey, “Muslim women’s knowledge, views, and attitudes towards sexually transmitted infections in Saudi Arabia: a qualitative study,” PLoS One, vol. 18, no. 6, Art. no. e0286822, Jun. 23, 2023.doi: 10.1371/journal.pone.0286822
[33] L. Shen, W. Zhang, Y. Yuan, W. Zhu, and A. Shang, “Vaginal microecological characteristics of women in different physiological and pathological periods,” Frontiers in Cellular and Infection Microbiology, vol. 12, Art. no. 959793, Jul. 22, 2022. doi: 10.3389/fcimb.2022.959793
[34] S. Dabee, J. A. Passmore, R. Heffron, and H. B. Jaspan, “The complex link between the female genital microbiota, genital infections, and inflammation,” Infection and Immunity, vol. 89, no. 5, Apr. 16, 2021. doi: 10.1128/IAI.00487-20.
[35] F. Sciarra, E. Franceschini, F. Campolo, D. Gianfrilli, F. Pallotti, D. Paoli, A. M. Isidori, and M. A. Venneri, “Disruption of circadian rhythms: a crucial factor in the etiology of infertility,” International Journal of Molecular Sciences, vol. 21, no. 11, p. 3943, May 30, 2020. doi:10.3390/ijms21113943.
[36] M. K. Collins, C. R. McCutcheon, and M. G. Petroff, “Impact of estrogen and progesterone on immune cells and host–pathogen interactions in the lower female reproductive tract,” The Journal of Immunology, vol. 209, no. 8, pp. 1437–1449, Oct. 15, 2022. doi: 10.4049/jimmunol.2200454.
[37] G. Duarte, I. M. Linhares, R. Kreitchmann, A. D. Tristão, E. Traina, I. Canti, M. Takimura, and J. Q. Andrade, “Vulvovaginitis in pregnant women,” Revista Brasileira de Ginecologia e Obstetrícia, vol. 46, Art. no. e-FPS03, Apr. 19, 2024. doi:10.61622/rbgo/2024FPS03
[38] R. M. Hameed and H. A. Abed, “Isolating and identifying yeasts in women with vaginal candidiasis and studying their ability to form biofilms and haemolysin,” Samarra Journal of Pure and Applied Science, vol. 6, no. 2/2, pp. 149–161, Aug. 30, 2024. https://doi.org/10.54153/sjpas.2024.v6i2/2.726
[39] L. M. Aziz, M. A. Hamad, E. M. Al-Hadethy, M. Saud, and F. R. Jameel, "Prevalence and Molecular detection of bacteria isolated from sexually transmitted disease in Al-Anbar Province," vol. 6, no. 5, pp. 1077-1086, 2023
[40] R. A. Mohammed, Z. S. Qajjam, and K. M. Mohammed, “Investigation of bacterial and fungal spp. causing vaginal infection in married Libyan women attending gynecology clinics in Aljmail City,” African Journal of Advanced Pure and Applied Sciences (AJAPAS), pp. 329–339, Dec. 17, 2023. https://aaasjournals.com/index.php/ajapas/article/view/646
[41] E. A. Ahmed, A. F. Arief, and R. R. Ali, “Assessment of pregnant women’s knowledge about vaginal yeast infection in Woman's Health Hospital, Assuit University,” Assiut Scientific Nursing Journal, vol. 12, no. 42, pp. 110–120, Feb. 1, 2024. doi: 10.21608/ASNJ.2024.273118.1796
[42] N. Osman, A. Ragab, S. Hassan, and H. F. Ibrahim, “Evaluating pregnant women’s knowledge regarding genital tract infections,” Mansoura Nursing Journal, vol. 10, no. 1, pp. 509–520, Jan. 1, 2023.
[43] S. A. Al-Hamzawi and G. R. Al-Awsi, “Prevalence of Trichomonas vaginalis and its correlation with socio-demographic variables in pregnant women in Al-Diwaniya, Iraq,” Materials Today: Proceedings, vol. 80, pp. 3847–3850, Jan. 1, 2023. https://doi.org/10.1016/j.matpr.2021.07.399
[44] H. A. Hamid, K. Jan, F. Gul, S. H. Jan, M. Rabnawaz, M. J. Ullah, and R. Bibi, “Prevalence of sexually transmitted infections among married women in Pakistan,” The Professional Medical Journal, vol. 32, no. 11, pp. 1562–1567, Nov. 2, 2025.https://doi.org/10.29309/TPMJ/2025.32.11.9998
[45] H. Elsayed and M. T. Amin, “Exploring the prevalence of chlamydial and gonorrheal infections in pregnant women: a multicenter study in Egypt,” Infection, vol. 1, p. 6, 2024. https://doi.org/10.1186/s12889-024-20239-9
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