Photonic Crystal-Based Biosensor for Measuring Glucose Concentration

Authors

  • Ahmed K. Tebeg Directorate of Education in Thi-Qar, Thi-Qar, Iraq.
  • Hassan A. Yasser Department of Physics, College of Science, University of Thi-Qar, Thi-Qar, Iraq

DOI:

https://doi.org/10.32792/utq/utjsci/v13i1.1460

Keywords:

photonic crystal, biosensor, glucose

Abstract

This work clearly demonstrated a response to changes in glucose concentration via a linear shift of the resonance wavelength with increasing concentration. The photonic crystal-based sensor was constructed using COMSOL based on the finite element method. Furthermore, it was shown that as the radius of the silver rod increased, plasmonic interferences and increased scattering caused the resonance spectrum (FWHM) to broaden and the quality factor to decrease. It was also shown that changing the radius (r1) of the photonic crystal material had an impact on the maximum transmittance, resonance wavelength, and spectrum width. Research findings showed that the largest detection limit was 2.25·10⁻⁴ RIU, and the best sensitivity was 500 nm/RIU at r1 = 0.123 μm. GaAs had the shortest spectrum width and best sensitivity, while TiO2 had the widest spectral range and the highest detection limit. These results suggested that the sensor could be a useful tool for accurately measuring glucose levels.

References

H. Wang, J. Yi, Y. Yu, and S. Zhou, “NIR upconversion fluorescence glucose sensing and glucose-responsive insulin release of carbon dot-immobilized hybrid microgels at physiological pH,” Nanoscale, Vol. 9, No. 2, pp. 509–516, 2017.

B. Arneth, R. Arneth, and M. Shams, “Metabolomics of type 1 and type 2 diabetes,” International Journal of Molecular Sciences, Vol. 20, No. 12 pp. 2467, 2019.

H. Yasser and M. Benhaliliba, “A plasmonic photonic crystal fiber sensor with simplified features for identifying unidentified analytes,” University of Thi-Qar Journal of Science, Vol. 1,No.1, pp. 709–756, 2024.

C. Rubio-Mercedes, N. Cunha, and J. Silva, “Numerical analysis of plasmonic couplers based on metallic lens,” Journal of Microwaves, Optoelectronics and Electromagnetic Applications, Vol. 22, No. 3, pp. 346–359, 2023.

J. Moses, S. Adibi, N. Wickramasinghe, L. Nguyen, M. Angelova, and S. Islam, “Non-invasive blood glucose monitoring technology in diabetes management: A review,” mHealth, Vol. 10, No. 9, pp. 9, 2024.

M. Sun, I. Li, W. Lin, and G. Lin, “Pros and cons of continuous glucose monitoring in the intensive care unit,” World Journal of Clinical Cases, Vol. 9, No. 24, pp. 8666–8670, 2021.

Y. Zhang, S. Chen, Y. Yu, and J. Wang, “A miniaturized photoacoustic device with laptop readout for point-of-care testing of blood glucose,” Talanta, Vol. 209, No. 1, pp. 120527, 2020.

T. Lin and A. Gal, “Non-invasive glucose monitoring: A review of challenges and recent advances,” Current Trends in Biomedical Engineering and Biosciences, Vol. 6, No. 3, pp. 1–8, 2017.

Q. Zhao, J. Liu, H. Yang, H. Liu, G. Zeng, B. Huang, and J. Jia, “Double U-groove temperature and refractive index photonic crystal fiber sensor based on surface plasmon resonance,” Applied Optics, Vol. 61, No. 25, pp. 7225–7230, 2022.

M. Bahadoran, A. Seyfari, P. Sanati, and L. Chua, “Label-free identification of the different status of anemia disease using optimized double-slot cascaded microring resonator,” Scientific Reports, Vol. 12, No. 1, pp. 1–10, 2022.

B. Liu, Y. Peng, Z. Jin, X. Wu, H. Gu, D. Wei, Y. Zhu, and S. Zhuang, “Terahertz ultrasensitive biosensor based on wide-area and intense light-matter interaction supported by QBIC,” Chemical Engineering Journal, Vol. 462, no. 1, pp. 142347, 2023.

M. Therese, P. Dharanyadevi, A. Devi, and C. Kalaiarasy, “Detection of blood glucose level in humans using non-invasive method-RL BGM,” International Journal of Recent Technology and Engineering, Vol. 9, No. 1, pp. 304–309, 2020.

H. Salman and H. Yasser, "Guided Modes in Slab Waveguide with Central Anisotropic Metamaterial Layer," IOP Conf. Series: Materials Science and Engineering, Vol. 928, No. 7, p. 072127, 2020.

H. Hameed and H. Yasser, "Three-Layer Slab Waveguide with Chiral Metamaterial Core and Graphene Interfaces," University of Thi-Qar Journal of Science, Vol. 11, No. 2, pp. 234–235, 2024.

R. Hani, B. Mahdi, and A. Mohammed, “Photonic crystal fiber sensor for blood with different concentrations of zinc,” Materials Science Forum, Vol. 1002, No. 2, pp. 290–299, 2020.

Y. Jiang, C. Shi, and J. Wang, “A hybrid plasmonic terahertz waveguide with ridge structure based on bulk-Dirac-semimetal,” Optics Communications, Vol. 475, No. 1, pp.233-237, 2020.

F. Wang, Y. Chen, C. Lie, T. Ma, X. Wang, K. Yu, and L. Li, “Ultracompact and broadband mid-infrared polarization beam splitter based on an asymmetric directional coupler consisting of GaAs-CaF2 hybrid plasmonic waveguide and GaAs nanowire,” Optics Communications, Vol. 502, No. 1, pp. 203–205, 2022.

J. Lee, M. Kim, and Y. Choi, “Series resistance influence on the performance of waveguide type germanium photodetectors on silicon,” Chinese Optics Letters, Vol. 15, No. 15, pp. 100401, 2017.

K. Kolwas and A. Kachova, “Impact of the interband transitions in gold and silver on the dynamics of propagating and localized surface plasmons,” Nanomaterials, Vol. 10, No. 12, pp. 1411, 2020.

S. Shaddod and H. Yasser, "Theoretical Study of Sensitivity of Slab-Sensor with Metamaterial," University of Thi-Qar Journal, Vol. 14, No. 1, pp. 267–275, 2019.

A. Kadhim and H. Yasser, “Effects of lattice types on the frequency bandwidths in photonic crystals,” University of Thi-Qar Journal of Science, Vol. 8, No. 2, pp. 80–85, 2021.

Z. Xing, W. Yang, Z. Yuan, X. Li, Y. Wu, J. Long, S. Jin, Y. Zhao, T. Liu, L. Bian, S. Lu, and M. Luo, “Growth and characterization of high in-content InGaN grown by MBE using metal modulated epitaxy technique (MME),” Journal of Crystal Growth, Vol. 516, No. 15, pp. 57–62, 2019.

B. Huard and G. Kirkham, “Mathematical modelling of glucose dynamics,” Current Opinion in Endocrine and Metabolic Research, Vol. 25, No. 1, pp. 100379, 2022.

N. Polyanskiy, "Refractiveindex.info database of optical constants," Scientific Data, Vol. 11, No. 21, pp. 94, 2024.

A. Uniyal, B. Chauhan, A. Pal, and V. Srivastava, “InP and graphene employed surface plasmon resonance sensor for measurement of sucrose concentration: A numerical approach,” Optical Engineering, Vol. 61, No. 5, pp. 057103, 2022.

H. Ali, H. Ammar, and H. Yasser, “Metal type effect on plasmonic fiber properties,” IOP Materials Science and Engineering, Vol. 31, No. 2, pp. 76, 2020.

Y. Yang, Y. Xiang, and X. Qi, “Design of photonic crystal biosensors for cancer cell detection,” Micromachines, Vol. 14, No.6, pp. 1478, 2023.

R. Arunkumar, T. Suaganya, and S. Robinson, “Design and analysis of 2D photonic crystal-based biosensor to detect different blood components,” Photonic Sensors, Vol. 9, No. 1, pp. 69–77, 2019.

A. Asuvaran and G. Elathrasan, “Design of two-dimensional photonic crystal-based biosensor for abnormal tissue analysis,” Silicon, Vol. 14, pp. 7203–7210, 2022.

R. Kumar, G. Bharti, and R. Bindal, “Modeling and simulation of an optical sensor for cancer cell detection,” International Journal of Electrical and Electronics Research, Vol. 10, No.3,pp. 792–795, 2022

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Published

2026-06-01

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How to Cite

Ahmed K. Tebeg, & A. Yasser, H. . (2026). Photonic Crystal-Based Biosensor for Measuring Glucose Concentration. University of Thi-Qar Journal of Science, 13(1), 25-33. https://doi.org/10.32792/utq/utjsci/v13i1.1460