Studying the relationship between mTOR activity and fertility hormones imbalances in polycystic ovary syndrome in Basra city

Authors

  • Asmaa Moslim Allawi Al-Mawanee Teaching Hospital, Basra Health Directorate, Ministry of Health, Iraq
  • Ali Mohammed Hadi Clinical Pharmacy Department, College of Pharmacy, University of Basrah, Iraq
  • Nisreen Waleed Mustafa2 Clinical Pharmacy Department, College of Pharmacy, University of Basrah, Iraq

DOI:

https://doi.org/10.32792/utq/utjsci/v12i1.1284

Keywords:

PCOS, mTOR, prolactin, testosterone, immunoregulation

Abstract

 

Polycysticovariansyndrome (PCOS) is an endocrine-related condition that is  world's leading cause of infertility affects women of reproductive age. The current study set out to investigate the effect of  mTOR functions on PCOS women and  its relation to fertility hormones. Total of 62 blood samples were collected, 42 of them were gathered from those who had recently been diagnosed with PCOS and 20 samples were collected from healthy women. The levels of mammalian target of rapamycin (mTOR) were measured using the (ELISA) technique while prolactin and testosterone were measured by Cobas e411. The study found a significant decrease in mTOR levels and a significant increase in prolactin and testosterone levels in women with PCOS compared to healthy women. Regarding age and BMI groups, no discernible variations were detected. This study concluded that dysregulation of mTOR is linked with PCOS, in addition, mTOR has a negative relationship with prolactin.

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Published

2025-06-08

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How to Cite

moslim, A., Mohammed Hadi, A. ., & Waleed, N. (2025). Studying the relationship between mTOR activity and fertility hormones imbalances in polycystic ovary syndrome in Basra city. University of Thi-Qar Journal of Science, 12(1), 24-29. https://doi.org/10.32792/utq/utjsci/v12i1.1284