The Relationship Between Iron Deficiency and Asthma Severity: Detection The Role of Gender and Ferritin Level
DOI:
https://doi.org/10.32792/utq/utjsci/v11i2.1269Keywords:
Asthma, IgE, Ferritin, Moderation analysis, Hemoglobin, HematocritAbstract
Emerging research suggests a complex interplay between asthma severity and ferritin levels, with evidence indicating that lower serum ferritin may be associated with increased asthma exacerbations, highlighting the potential role of iron homeostasis in respiratory health and disease management. The study aims to examine the impact of ferritin levels on asthma severity, assess the moderating effect of gender, and identify biomarkers that exacerbate symptoms in the context of low ferritin. This study enrolled 180 individuals over 18 years, including 120 allergic asthma patients and 60 healthy controls. Asthma patients were categorized based on ferritin levels into 43 males and 17 females with normal levels, and 17 males and 43 females with low levels. The study excluded individuals with other respiratory, autoimmune, or oncologic diseases, and smokers. Blood samples were collected for complete blood count (CBC), ferritin, and Immunoglobulin E (IgE) measurements, with serum samples frozen at -70°C for further analysis. Out of 180 participants, 120 (66.6%) were asthma cases, split evenly between normal and low ferritin levels. The study found significant hematocrit differences (P < 0.01), with the lowest levels in the low ferritin asthma group (35.18 ± 6.74). Ferritin and IgE levels varied markedly across groups (P < 0.05 and P < 0.001, respectively), with the lowest ferritin (9.80 ± 2.39 ng/ml) and highest IgE (327.91 ± 106.81 IU/ml) in the low ferritin asthma group. Regression analysis showed an inverse relationship between ferritin levels and asthma severity (B = -20.46, P < 0.001),
Received: 2024-06-09
Revised: 2024-07-06
Accepted: 2024-07-18
References
M. A. Bejeshk, A. Beik, A. H. Aminizadeh, F. Salimi, F. Bagheri, M. Sahebazzamani, et al., "Perillyl alcohol (PA) mitigates inflammatory, oxidative, and histopathological consequences of allergic asthma in rats," Naunyn-Schmiedeberg's Archives of Pharmacology, vol. 396, pp. 1235-1245, 2023.
W. Burke, M. Fesinmeyer, K. Reed, L. Hampson, and C. Carlsten, "Family history as a predictor of asthma risk," American journal of preventive medicine, vol. 24, pp. 160-169, 2003.
T. Liu, R. Valdez, P. W. Yoon, D. Crocker, R. Moonesinghe, and M. J. Khoury, "The association between family history of asthma and the prevalence of asthma among US adults: National Health and Nutrition Examination Survey, 1999–2004," Genetics in Medicine, vol. 11, pp. 323-328, 2009.
E. R. Sutherland, "Linking obesity and asthma," Annals of the New York Academy of Sciences, vol. 1311, pp. 31-41, 2014.
R. Polosa and N. C. Thomson, "Smoking and asthma: dangerous liaisons," European respiratory journal, vol. 41, pp. 716-726, 2013.
Y. Solomon, N. A. Gebeyehu, G. A. Adella, G. A. Kassie, M. A. Mengstie, M. A. Seid, et al., "Prevalence of anemia and its associated factors among adult asthmatic patients in Northwest Ethiopia," BMC Pulmonary Medicine, vol. 23, p. 222, 2023.
N. Habib, M. A. Pasha, and D. D. Tang, "Current understanding of asthma pathogenesis and biomarkers," Cells, vol. 11, p. 2764, 2022.
M. N. Garcia-Casal, S.-R. Pasricha, R. X. Martinez, L. Lopez-Perez, and J. P. Pena-Rosas, "Serum or plasma ferritin concentration as an index of iron deficiency and overload," Cochrane Database of Systematic Reviews, 2021.
H. A. Ali, T. E. Deraz, N. I. Reyad, Y. H. Mohammed, and A. A. Husseiny, "Iron status and its relation to lung function in pediatric asthmatics: a cross-sectional study," The Egyptian Journal of Bronchology, vol. 16, p. 46, 2022.
M. K. Ali, R. Y. Kim, A. C. Brown, J. R. Mayall, R. Karim, J. W. Pinkerton, et al., "Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma," European Respiratory Journal, vol. 55, 2020.
D. Zajac, "Mineral micronutrients in asthma," Nutrients, vol. 13, p. 4001, 2021.
F. Roth-Walter, "Iron-deficiency in atopic diseases: innate immune priming by allergens and siderophores," Frontiers in Allergy, vol. 3, p. 859922, 2022.
E. P. Brigham, M. C. McCormack, C. M. Takemoto, and E. C. Matsui, "Iron status is associated with asthma and lung function in US women," PloS one, vol. 10, p. e0117545, 2015.
J. Burtscher, Q. Pasha, N. Chanana, G. P. Millet, M. Burtscher, and B. Strasser, "Immune consequences of exercise in hypoxia: a narrative review," Journal of Sport and Health Science, vol. 13, pp. 297-310, 2024.
S. Guardado, D. Ojeda-Juárez, M. Kaul, and T. M. Nordgren, "Comprehensive review of lipocalin 2-mediated effects in lung inflammation," American Journal of Physiology-Lung Cellular and Molecular Physiology, vol. 321, pp. L726-L733, 2021.
X. Lv, M. Dong, W. Tang, J. Qin, W. Wang, M. Li, et al., "Ferroptosis, novel therapeutics in asthma," Biomedicine & Pharmacotherapy, vol. 153, p. 113516, 2022.
Z. Zeng, H. Huang, J. Zhang, Y. Liu, W. Zhong, W. Chen, et al., "HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma," The FASEB Journal, vol. 36, p. e22359, 2022.
M. S. Allai, Z. A. Shah, K. H. Changal, M. A. Raina, and F. A. Bhat, "Association of low levels of vitamin D with chronic stable angina: A prospective case-control study," North American journal of medical sciences, vol. 8, p. 143, 2016.
M. Masoli, D. Fabian, S. Holt, R. Beasley, and G. I. f. A. Program, "The global burden of asthma: executive summary of the GINA Dissemination Committee report," Allergy, vol. 59, pp. 469-478, 2004.
K. Ramakrishnan and A. Borade, "Anemia as a risk factor for childhood asthma," Lung India, vol. 27, pp. 51-53, 2010.
K. Ramakrishnan and P. Harish, "Hemoglobin level as a risk factor for lower respiratory tract infections," The Indian Journal of Pediatrics, vol. 73, pp. 881-883, 2006.
S. Mourad, M. Rajab, A. Alameddine, M. Fares, F. Ziade, and B. Abou Merhi, "Hemoglobin level as a risk factor for lower respiratory tract infections in Lebanese children," North American journal of medical sciences, vol. 2, p. 461, 2010.
A. Bener, M. S. Ehlayel, and Q. Hamid, "The impact of anemia and hemoglobin level as a risk factor for asthma and allergic diseases," Indian Journal of Allergy, Asthma and Immunology, vol. 29, pp. 72-78, 2015.
H. M. Rashid, M. Khan, M. Jamal, and W. Shah, "Anemia in Asthmatic Females exaggerates the severity of inflammation in Asthma by Inducing Dyslipidemia, High levels of IgE and Absolute Eosinophil count: role of anemia on female asthmatic patient’s lipidemia, IgE and eosinophil count," Proceedings of the Pakistan Academy of Sciences: B. Life and Environmental Sciences, vol. 56, pp. 9–14-9–14, 2019.
M. Schatz and C. A. Camargo Jr, "The relationship of sex to asthma prevalence, health care utilization, and medications in a large managed care organization," Annals of allergy, asthma & immunology, vol. 91, pp. 553-558, 2003.
E. Wang, M. E. Wechsler, T. N. Tran, L. G. Heaney, R. C. Jones, A. N. Menzies-Gow, et al., "Characterization of severe asthma worldwide: data from the International Severe Asthma Registry," Chest, vol. 157, pp. 790-804, 2020.
L. Cevhertas, I. Ogulur, D. J. Maurer, D. Burla, M. Ding, K. Jansen, et al., "Advances and recent Developments in asthma in 2020," Allergy, vol. 75
, pp. 3124-3146, 2020.
L. P. Hale, E. P. Kant, P. K. Greer, and W. M. Foster, "Iron supplementation decreases severity of allergic inflammation in murine lung," 2012.
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