A, Assessment the Effects of Heavy Elements on Some Hematological Parameter in CKD Patients Undergoing Hemodialysis in Thi-Qar Province / Iraq .
DOI:
https://doi.org/10.32792/utq/utjsci/v11i2.1192Keywords:
Heavy elements , Chronic kidney disease , Complete blood count , hemodialysis , Dhi-Qar Province.Abstract
The present study aimed to assess the level of heavy elements (HEs) (Pb, Cd, Cu and Zn) in blood serum and their effects upon selected parameters (WBC, RBC, Hb and PLT.) in patients with chronic kidney disease (CKD) undergoing hemodialysis (HD) in Thi-Qar province Iraq. The study was from Sept 2022 until July 2023. Fifty samples of blood were taken from patients with CKD, whereas 25 samples were takenfrom healthy people (males and females as a control group. The patients and the controlroup ranged from (17-76) years. All the patients were submitted to the HD for (1-15) yeas in Al-Hussain Hospital in the mentioned province. The results showed that the sex ratio of the samples was more than 70% for males and 30% females respectively, and the high number of the patients with CKD was 48% for the advance age group (57-76). The mean concentration of (Cd, Cu, Zn and Pb) in the blood serum of patients pre HD were 0.065±0.018, 0.014±0.006, 0.016±0.008 and 1.041±0.38 mg/L respectively, Pb and Cd recorded the higher mean concentration, while Cu and Zn recorded lower concentration compared to the control group .The mean count of (WBC, RBC, Hb and PLT) were decreased , recorded 2.78±0.79, 3.06±0-54, 8.54±1.43 and 164.4±51.8 respectively , it concluded from the present study that the CKD affected the hematological parameters directly while HEs affected indirectly.
Received: 2024-03-11
Revised: 2024-04-24
Accepted: 2024-05-11
References
H. Yang, and N. Rose , "Distribution of Hg in the lake sediments across the UK", Sci. Total Environ, 304(1-3): 391 – 404.2003.
C. Damien, V. Chantal, H. Pirouz, S., Zerimech, F., Laurence, and M. H. Jean, "Cellular impact of elementtrace elements in terricolous lichen Diploschistes muscorum (Scop.)R. Sant. –identification of oxidative stress biomarkers", Water Air Soil Pollut, 152(1):55-69 .2004.
M. Aliasgharpour, "Trace elements in human nutritionn (II)–an update", Int J Prev Med.11(1):11-12. 2020.
L. Prashanth, KK. Kattapagari, RT. Chitturi, VRR. Baddam, and LK. Prasad, "A review on role of essential trace elements in health and disease", J dr ntr Univ Heal Sci. 4(2):75. 2015.
E. Sabath, and M.L. Robles-Osorio, " Renal health and the environment: heavy element nephrotoxicity", Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia, 32 (3), 279-86 .2012.
A. Keshav Krishna, and K. Rama Mohan "Distribution, correlation, ecological and health risk assessment of heavy element contamination in surface soils around an industrial area, Hyderabad, India ", Environ Earth Sci. 75(5):1-17.2016.
E. O. Farombi, O. A. Adelowo, and Y. R. Ajimoko," Biomarkers of oxidative stress and heavy elementlevels as indicators of environmental pollution in African Cat fish (Clarias gariepinus) from Nigerian Ogun River", Int. J. Environ. Res. Public Health, 4(2): 158 – 165.2007.
E. O. Chielle, K. A. Rigon, I. A. Arcari, V. Stein, and G. A. D. Santos, " Influence of hemodialysis on the plasma concentration of adenosine deaminase in patients with chronic kidney disease Santos, "Jornal Brasileiro de Patologia e Medicina Laboratorial, 51 (3): 153-157 . 2015.
V. Jha, G. Garcia-Garcia, Iseki K, et. al," Chronic kidney disease: global dimension and perspectives ", Lancet, 382(9888):260–72.2013.
Y. Chen, X. Xu, Z. Zeng, X. Lin, Q. Qin and X. Huo , "Blood lead and cadmium levels associated with hematological and hepatic functions in patients from an e-waste-polluted area", Chemosphere, Volume 220, Pages 531-538, ISSN 0045-6535.2009.
K. Nitta, K. Okada, M. Yanai, et. al. "Aging and chronic kidney disease", Kidney Blood Press .38(1):109–20.2014.
E. O. Chielle, K. A. Rigon, I. A. Arcari, V. Stein, and G. A. D . Santos, " Influence of hemodialysis on the plasma concentration of adenosine deaminase in patients with chronic kidney disease", Jornal Brasileiro de Patologia e Medicina Laboratorial, 51(3) : 153-157 .2015.
R.A. Hamer and A.M. El Nahas," The burden of chronic kidney disease", BMJ .332(2):563– 4. 2006.
V. Jha, G. Garcia-Garcia, K Iseki., et al.," Chronic kidney disease: global dimension and perspectives", Lancet .382(9888):260–72.2013.
J.L. Babitt and HY. Lin, "Mechanisms of anemia in CKD", J Am Soc Nephrol .23 (10):1631– 4.2012.
R. Mahmood, SA. Khan and A. Mustafa, "Study about Renal Profile in Patients of Chronic Kidney Disease Undergoing Hemodialysis", Asian J Multidiscip Stud. 8 (1). 1518-8345.2020.
X. Ji and J. Ren," Determination of copper and zinc in serum by derivative atomic absorption spectrometry using the microsampling" , 2002.
S. Satarug, "Dietary cadmium intake and its effects on kidneys", Toxics.6 (1):15.2018.
I. Pócsi, ME Dockrell and RG. Price, "Nephrotoxic biomarkers with specific indications for metallic pollutants", Implications for environmental health. Biomark Insights. 17 (1-13):11772719221111882.2022.
H.K. Aggarwal, D. Jain and A. Bhavikatti, "Cognitive dysfunction in patients with chronic kidney disease", Saudi J Kidney Dis Transplant. 31(4):796.2020.
A.M. Bernard, H. Roels, A. Cardenas and R. Lauwerys, "Assessment of urinary protein 1and transferrin as early markers of cadmium nephrotoxicity", Br J . Ind Med .47 (8):559–565.1990.
S.R. Mendley, A. Levin, R. Correa-Rotter, et. al. "Chronic kidney diseases in agricultural communities: report from a workshop", Kidney Int. 96 (5):1071-1076.2019.
KB. Egan, CR. Cornwell, JG. Courtney , and AS. Ettinger, "Blood lead levels in US children ages 1–11 years", 1976–2016. Environ Health Perspect. 129(3):37003.2021.
SE. Orr ,and CC. Bridges," Chronic kidney disease and exposure to nephrotoxic metals", Int J Mol Sci. 18(5):1039.2017.
M. Tonelli, N. Wiebe , B. Hemmelgarn et al. . "Trace elements in hemodialysis patients: a systematic review and meta-analysis ", BMC Medicine 7:25 doi:10.1186/1741-7015-7-25.2009.
N. Reena, P. Deepti, K. Ashok, et al. . "Trace elements and antioxidant enzymes associated with oxidative stress in the preeclamptic/ eclamptic mothers during fetal circulation", Clinical nutrition. 31(6):946-50.2012.
S. Fishbane , "Iron supplementation in renal anemia", Semin Nephrol ,26(4):319-324.2006.
K. H. Mahdi , H. H. Al-Ghanimi and R. M. Al-Dedah , "Haematological Parameters and Biochemical Indices in Patients with Chronic Kidney Disease Before Haemodialysis Al-Furat Al-Awsat Governorates / Iraq", The 8th International Conference on Applied Science and Technology, AIP Conf. Proc. 2290(1); 020004-1–020004-13.2020.
S. Singh , and S. Bhatta , "Biochemical And Hematological Parameters In Chronic Kidney Disease" , Journal of Manmohan Memorial Institute of Health Sciences ,4(1),4-11.2018.
A. Habib, R. Ahmad, and S. Rehman , "Hematological changes in patients of chronic renal failure and the effect of hemodialysis on these parameters" .International Journal of Research in Medical Sciences , 5(11):4998-5003.2017.
S. Wahab, "Study of HEs and their effects on Oxidant / Antioxidant Status in Workers of fuel Station in Hilla city-Iraq" , Research J. Pharm. and Tech. 11(1): ISSN 0974-3.2018.
S.Y. Kim, JK. Choi, Y.H. Cho, E.J. Chung, D. Paek , and H.W. Chung, " Chromosomal aberrations in workers exposed to low levels of benzene: association with genetic polymorphisms", Pharmacogenet Genom. 14(7):453–463.2004
L. J. Langman, and B. M. Kapur, "Toxicology: then and now", Clinical biochemistry, 39(5),498–510. 2006
A. Bernard, "Renal dysfunction induced by cadmium: biomarkers of critical effects", Biometals : an international journal on the role of elementions in
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