Synthesis, Characterization and Anticancer Study of New3-[(2Z)-2(2-hydroxybenzylidene) hydrazinyl]-5-(2-hydroxyphenyl)-1, 3, 4-oxadiazol-3-ium and its Transition Metal Complexes
DOI:
https://doi.org/10.32792/utq/utjsci/v10i2.1094Keywords:
Transitions metal complexes, anticancer, 1.3.4-oxadiazoleAbstract
A new ligand 2-{5-[2-(2-hydroxybenzylidene)hydrazinyl]-1,3,4-oxadiazol-2-yl}phenol (L) was prepared and characterized by Infrared Spectra, H1 Nuclear magnatic resonance, C13 Nuclear magnatic resonance , and mass spectroscopy. ligand was used as chelating ligand to prepare some of transition metal complexes with Ni(II), Co(II), and Cr(III). The prepared complexes were characterized by FTIR, mass spectroscopy and conductance measurement. The hyper chem. program 7.51 was used for theoretical study using PM3 methodor the purpose of this study,. Regarding the information obtained about the complexes, we can suggest the octahedral geometry for Cr (III) complex, tetrahedral geometry for Co(II) and square planer for Ni(II). The effectiveness of these ligands against the breast cancer was studied and showed excellent results. the most active derivatives of 1,3,4-oxadiazole exceeded the effect of reference drugs, so they may become the main new anti-cancer drugs in the future.
Received: 2023-07-24
Revised: 2023-08-29
Accepted: 2023-09-11
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