Effect of Chemotherapy on hs- C Reactive Protein, Some Blood Picture and Kidney Function in Patients With Neuroblastoma


  • sama yaqoob College of Science/ University of Thi-Qar
  • Jamal Alsaadi College of Science/ University of Thi-Qar




Neuroblastoma, chemotherapy, hs-CRP, kidney function test, CBC.


Background: Neuroblastoma, the most common extra-cranial malignant pediatric solid tumor and one with a high mortality rate. Children suffering from Neuroblastoma after chemotherapy suffer from anemia, severe infections, and effects on some organs of the body. Therefore, the current study aims to study the effect of chemotherapy on inflammatory factor (high-sensitivity C-reactive Protein), some hematological parameters such as white blood cells, platelets, and hemoglobin, and some kidney function such as urea and Creatinine in children with Neuroblastoma before and after three cycles of chemotherapy.

 Materials and methods:  70 cases were divided into three groups: Group A;  35 healthy children are included as a control group., and  group B; consists of 35 newly diagnosed patients   and  group C; following three chemotherapy rounds (same patients newly diagnosed), with an age range from 2 months to 12 years. They had attended Basrah Specialist Hospital for Children from May 2022 to the end of March 2023. Results: When compared to the control group, the results of the current study showed a significant rise (p˂0.05) in the levels of high-sensitivity C-reactive protein, white blood cells, and platelets in the sera samples of patients with Neuroblastoma

Conclusion: This study came to the conclusion that Neuroblastoma treatment considerably changed a number of hematological markers and hs-crp. Consequently, it is essential to monitor these signs.

Author Biography

  • Jamal Alsaadi, College of Science/ University of Thi-Qar






Y. Koga et al., “Infantile neuroblastoma and maternal occupational exposure to medical agents,” Pediatr. Res., no. April, pp. 1–5, 2021, doi: 10.1038/s41390-021-01634-z.

A. J. Murphy, M. White, and P. S. W. Davies, “Body composition of children with cancer,” Am. J. Clin. Nutr., vol. 92, no. 1, pp. 55–60, 2010.

A. Winther-Larsen, N. Aggerholm-Pedersen, and B. Sandfeld-Paulsen, “Inflammation-scores as prognostic markers of overall survival in lung cancer: a register-based study of 6,210 Danish lung cancer patients,” BMC Cancer, vol. 22, no. 1, pp. 1–10, 2022.

S. Lee, J. W. Choe, H. K. Kim, and J. Sung, “High-sensitivity C-reactive protein and cancer,” J. Epidemiol., vol. 21, no. 3, pp. 161–168, 2011.

Y. Zhou et al., “Clinical effectiveness of matrine sitz bath in treating perianal infection after chemotherapy for acute leukemia,” Ann. Cardiothorac. Surg., vol. 9, no. 3, pp. 1109–1116, 2020, doi: 10.21037/apm-20-912.

C. Qi et al., “The prognostic value of the advanced lung cancer inflammation index (ALI) for patients with neuroblastoma,” J. Int. Med. Res., vol. 50, no. 6, 2022, doi: 10.1177/03000605221109382.

J. Jagieła, P. Bartnicki, and J. Rysz, “Nephrotoxicity as a complication of chemotherapy and immunotherapy in the treatment of colorectal cancer, melanoma and non-small cell lung cancer,” Int. J. Mol. Sci., vol. 22, no. 9, pp. 1–17, 2021.

L. Agnello, R. Giglio, G. Bivona, C. Scazzone, C. Gambino, A. Iacona, A. Ciaccio, B. Sasso, and M. Ciaccio,

“The value of a complete blood count (Cbc) for sepsis diagnosis and prognosis,” Diagnostics, vol. 11, no. 10, pp. 1–19, 2021.

I. H. Seo and Y. J. Lee, “Usefulness of Complete Blood Count (CBC) to Assess Cardiovascular and Metabolic Diseases in Clinical Settings: A Comprehensive Literature Review,” Biomedicines, vol. 10, no. 11, 2022.

H. Talke, G. Schubert, Klin. Wochschr., 19, (1965), 43, p.174.

H. Bartels and M. Bohmer, Clin. Chem. Acta. 1972, .37: 193.

C. Zheng, S. Liu, J. Feng, and X. Zhao, “Prognostic value of inflammation biomarkers for survival of patients with neuroblastoma,” Cancer Manag. Res., vol. 12, pp. 2415–2425, 2020.

A. G. Small et al., “Neuroblastoma, body mass index, and survival: a retrospective analysis,” Med. (United States), vol. 94, no. 14, pp. 1–6, 2015, doi: 10.1097/MD.0000000000000713.

P. Nabapally, “Study on the Levels of CRP Among the Cancer Patients Before and After Chemotherapy Treatment,” Indian J. Res., vol. 5, no. 8, pp. 88–89, 2016.

L. Hempel et al., “Influence of high-dose methotrexate therapy (HD-MTX) on glomerular and tubular kidney function,” Med. Pediatr. Oncol., vol. 40, no. 6, pp. 348–354, 2003, doi: 10.1002/mpo.10293.

M. E. Scheurer et al., “An overview of disparities in childhood cancer: Report on the Inaugural Symposium on Childhood Cancer Health Disparities, Houston, Texas, 2016,” Pediatr. Hematol. Oncol., vol. 35, no. 2, pp. 95–110, 2018.

Ministry of health, Iraqi Cancer Board. (2017): Results of Iraqi Cancer Registry 2017.

B. Wondimneh, S. A. D. Setty, G. G. Asfeha, E. Belay, G. Gebremeskel, and G. Baye, “Comparison of hematological and biochemical profile changes in pre-and post-chemotherapy treatment of cancer patients attended at ayder comprehensive specialized hospital, mekelle, northern ethiopia 2019: A retrospective cohort study,” Cancer Manag. Res., vol. 13, pp. 625–632, 2021.

Z. Aljoubouri, “A Physiological and Biochemical Study of Acute Lymphoblastic Leukemia in Iraqi Children before and after Chemotherapy“, Ph.D. Thesis in Zoology, Dept. of Biology/ College of Education for Pure Sciences/ University of Karbala, PP. 246, 2021

S. Anoar, “Effect of chemotherapy on vitamin B12, folic acid and some biochemical factors on leukemia (chronic myeloid leukemia) in Iraqi patients“. PhD. Thesis, Dept., of Biology/ College of Education Ibn Al-Haitham/ University of Baghdad, Pp:104. 2006.

M. Di Maio et al., “The prognostic role of pre-chemotherapy hemoglobin level in patients with ovarian cancer,” Front. Biosci., vol. 11, pp. 1585–1590, 2006.

H. Abdel-Razeq and H. Hashem, “Recent update in the pathogenesis and treatment of chemotherapy and cancer induced anemia,” Crit. Rev. Oncol. Hematol., vol. 145, no. August 2019, p. 102837, 2020.

S. Vignjević Petrinović, A. Jauković, M. Milošević, D. Bugarski, and M. Budeč, “Targeting Stress Erythropoiesis Pathways in Cancer,” Front. Physiol., vol. 13, no. May, pp. 1–14, 2022.








How to Cite

Effect of Chemotherapy on hs- C Reactive Protein, Some Blood Picture and Kidney Function in Patients With Neuroblastoma . (2023). University of Thi-Qar Journal of Science, 10(2), 81-86. https://doi.org/10.32792/utq/utjsci/v10i2.1090