Estimation of NLRP3 Inflammasome Role and some Biochemical Parameters in Patients with Chronic Kidney Diseases (CKD)


  • Nada Hussain Alwan College of Science/ University of Thi-Qar
  • Hadeel Faraj University of Thi-Qar



Chronic Kidney Disease , NLRP3 inflammasome , Inflammation marker and kidney function tests. .


Chronic kidney disease (CKD) is a widespread condition that poses a major threat to human health. With substantial public health costs, severe morbidity, and mortality, CKD prevalence is increasing. The study aimed to look at NLRP3 inflammasome , hsCRP , Urea , Creatinine, Uric acid and GFR levels. Serum NLRP3 inflammasome , hsCRP , Urea , Creatinine, Uric acid and GFR levels were determined in 90 patients with Chronic Kidney Diseases (CKD) , and 85 healthy subjects, an age range (30-75). The results  of  current  study  show a significant increase in the concentration of serum NLRP3 inflammasome, hs-CRP, urea , creatinine and uric acid in (CKD) patients group in comparison with controls group (p<0.05). While shows a significant decrease in GRF in (CKD) patients group in comparison with controls group (p<0.05). The aim of this study is estimated the NLRP3 inflammasome ,  Inflammation marker ,  kidney function tests  and Glomerular  filtration rate (GFR)  in patients with Chronic Kidney Disease.


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Article Dates

Published: 2023-12-22

How to Cite

Nada Hussain Alwan, & Faraj, H. (2023). Estimation of NLRP3 Inflammasome Role and some Biochemical Parameters in Patients with Chronic Kidney Diseases (CKD). University of Thi-Qar Journal of Science, 10(2), 16–19.