Evaluation the Role of Preptin Hormone and some Biochemical Parameters in Type2 Diabetic Patients with Cardiovascular disease


  • Redaa J. Abdul Hussein Department of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, 64001, Iraq.
  • Alyaa Majid University of Thi-Qar- College of Science- Department of Chemistry




Myocardial infraction, Type 2 diabetes, Preptin, Lactate dehydrogenase, Fasting Blood glucose


Background: Type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD) poses major threat worldwide contributing to excessive morbidity and mortality, these co-morbidities synergistically interact with inflammatory mechanisms. The study aimed to observe levels the Preptin, Lactate dehydrogenase (LDH), Fasting Blood glucose (FBG). Methods: Serum Preptin, LDH and FBG levels were determined in 50 patients with acute myocardial infraction , 50 patients with (type 2 diabetes with myocardial infraction) and 50 healthy subjects. Results: The results show a significant increase in the concentration of serum (Preptin, LDH and FBG) in (T2DM with AMI) group in comparison with the (AMI and controls) groups (p?0.05). But it was found no significant deference in the concentration of serum Preptin and FBG between (AMI and controls) groups (p?0.05). Also it was found no significant deference in the concentration of serum LDH between (AMI with T2DM and AMI) groups (p?0.05). Conclusion: Assessment of preptin with lactate dehydrogenase and fasting glucose may predict pancreatic as well as cardiac dysfunction and its helpful in stratification of severity risk.

Author Biography

Redaa J. Abdul Hussein, Department of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, 64001, Iraq.



Abbas A, Ali H A, AL-Rufaie M M, & Ali R A. (2019). Association of serum preptin levels with insulin resistance in Iraqi women with gestational diabetes mellitus. Int Res J Pharm.;10, 49-55.?

Abed W T, Jassim W E, & Rasheed E M. (2022). Detection of preptin and insulin like growth factor 2 receptor in the sera of type 2 diabetic patients in Kirkuk city.; 140(01),1597-1606.

Ahmad AJ, Khan A, Khan S, Manzoor K.(2017).Causes, complication and management of diabetes mellitus. Chronicle Journal of food and Nutrition; 1,1-3.

Al-Abbas W D S. (2019). Evaluation the Role of Interleukin-8 and Interleukin-10 in Myocardial Infarction Patients in Al-Najaf City. University of Thi-Qar Journal of Science.; 7(1), 84-88.?

Auda M A, Majid A, Al-Fartosi K G. (2018). Protective role of polyphenolic compounds extracted from cyperus rotundus rhizomes and taurine on troponin-I and some oxidant/antioxidants parameters of female rats treated with isoproterenol–induced myocardial infraction. Journal of Thi-Qar University.;Vol: 13(2),61-76.

Ding J, Karp J E, Emadi A. (2017). Elevated lactate dehydrogenase (LDH) can be a marker of immune suppression in cancer: Interplay between hematologic and solid neoplastic clones and their microenvironments. Cancer Biomarkers.; 19(4), 353-363.?

Ejan Aoife M, Dinneen Seán F.(2019). What is diabetes?. Medicine.; 47(1): 1-4.?

Faris Rija F, Sulaiman Musa M I, Hamad H T. (2022). Some Biochemical Parameters and Level of Preptin in Newly Diagnosed Type 2 Diabetic Women Patients in Tikrit City. Journal of Chemical Health Risks.;12(2), 179-182.?

Graham I, Atar D, Borch-Johnsen K, Boysen G, Burell G, Cifkova R, Zampelas A. (2007). European guidelines on cardiovascular disease prevention in clinical practice: executive summary: Fourth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by representatives of nine societies and by invited experts). European heart journal.;28(19), 2375-2414.?

Kalayci, Mehmet, et al.(2019). Plasma preptin levels in patients with type 2 diabetes mellitus. International Journal of Medical Biochemistry.; 2(1): 1-5.

Lee J J, Beretvas S N, Freeland-Graves J H. (2014). Abdominal adiposity distribution in diabetic/prediabetic and nondiabetic populations: a meta-analysis. Journal of obesity.; 2014,1-20.

Lu L, Liu M, Sun R, Zheng Y, Zhang P. (2015). Myocardial infarction: symptoms and treatments. Cell biochemistry and biophysics.; 72, 865-867.?

Majid A, Sayer S A. (2018). Protective effect of phenolic extract of Cyperus rotundus rhizomes on myocardial infarction induced by isoproterenol in female rats. In IOP Conference Series: Materials Science and Engineering.; (Vol. 454, No. 1, p. 012005). IOP Publishing.?

Mendis S, Thygesen K, Kuulasmaa K, Giampaoli S, Mähönen M, Ngu Blackett K, & Writing group on behalf of the participating experts of the WHO consultation for revision of WHO definition of myocardial infarction. (2011). World Health Organization definition of myocardial infarction: 2008–09 revision. International journal of epidemiology.;40(1), 139-146.?

Nishio K, Shigemitsu M, Kusuyama T, Fukui T, Kawamura K, Itoh S, Katagiri T. (2006). Insulin resistance in nondiabetic patients with acute myocardial infarction. Cardiovascular Revascularization Medicine.;7(2), 54-60.?

Puleo P R, Meyer D, Wathen C, Tawa C B, Wheeler S, Hamburg R J, Roberts R. (1994). Use of a rapid assay of subforms of creatine kinase MB to diagnose or rule out acute myocardial infarction. New England Journal of Medicine.; 331(9), 561-566.?

Wang R, Xue A, Zheng W, Wang L, Yan F, Hu W, He L. (2019). Elevated serum preptin concentrations in patients with diabetic nephropathy. Journal of Investigative Medicine.; 67(7), 1048-1052.?

Wong S S. (1996). Strategic utilization of cardiac markers for the diagnosis of acute myocardial infarction. Annals of Clinical & Laboratory Science.;26(4), 301-312.?

Wu A H, Apple F S, Gibler W B, Jesse R L, Warshaw M M, Valdes Jr R. (1999). National Academy of Clinical Biochemistry Standards of Laboratory Practice: recommendations for the use of cardiac markers in coronary artery diseases. Clinical chemistry.;45(7), 1104-1121.?

Wu, Yuling. (2021). Serum lactate dehydrogenase activities as systems biomarkers for 48 types of human diseases. Scientific Reports.;11.1: 1-8.?





How to Cite

J. Abdul Hussein, R., & Majid, A. (2023). Evaluation the Role of Preptin Hormone and some Biochemical Parameters in Type2 Diabetic Patients with Cardiovascular disease. University of Thi-Qar Journal of Science, 10(1). https://doi.org/10.32792/utq/utjsci/v10i1.1035