Overview of the Biochemical Potential of Solanum Nigrum


  • Noor Abd alKhudhur salman Department of Chemistry, College of Science, University of Thi-Qar, Iraq




Solanum nigrum, Alkaloids, Antioxidant, Anticancer.


Solanum nigrum is known locally as the nightshadesamily, and it is considered one of the widespread plants that possess great biochemical potential. This review dealt with providing a comprehensive summary of the biochemistry of this plant, as it contains Solanum nigrum. It contains an important group of biologically active substances, including flavonoids, and some phenolic derivatives. It also contains some alkaloids, epoxy derivatives, and other important compounds. These substances have important biological activity, including significant and powerful antioxidant and anti-inflammatory properties, as well as strong antimicrobial and anti-cancer properties, and other medically important properties. This plant has been used for medicinal purposes for a long time in treating many diseases. Finally, this review indicates the wide biological diversity in biochemistry. The study also touched on some potential applications in various fields, including nutrition and medicine.



M. A. B. Nyeem, A. Rashid, M. Nowrose, and M. A. Hossain, "Solanum nigrum (Maku): A review of pharmacological activities and clinical effects," IJAR, vol. 3, pp. 12-17, 2017.

P. Rani and N. Khullar, "Antimicrobial evaluation of some medicinal plants for their anti‐enteric potential against multi‐drug resistant Salmonella typhi," Phytotherapy Research: An International Journal Devoted to Pharmacological and Toxicological Evaluation of Natural Product Derivatives, vol. 18, pp. 670-673, 2004.

F. Atanu, U. Ebiloma, and E. Ajayi, "A review of the pharmacological aspects of Solanum nigrum Linn," Biotechnol Mol Biol Rev, vol. 6, pp. 1-7, 2011.

A. Pandey, A. Dwivedi, and I. Tripathi, "Review Article on Pharmaceutical, Pharmacological Activities and Therapeutic Potential of “S. nigrum”," International Journal of Research in Engineering and Science, vol. 9, pp. 1-7, 2021.

B. Thejaswini, S. Satish, and R. Shabaraya, "A review on Pharmacological potential of Solanum nigrum: Pharmacological review on Solanum nigrum," Indian Journal of Pharmacy & Drug Studies, vol. 2, pp. 95-102, 2023.

G. Arunachalam, N. Subramanian, G. P. Pazhani, M. Karunanithi, and V. Ravichandran, "Evaluation of Anti-inflammatory Activity of Methanolic Extractof Solanum nigrum (Solanaceae): Anti-inflammatory effect of Solanum nigrumLinn extract," Iranian Journal of Pharmaceutical Sciences, vol. 5, pp. 151-156, 2009.

S. Mandal, P. Vishvakarma, M. Verma, M. S. Alam, A. Agrawal, and A. Mishra, "Solanum Nigrum Linn: An Analysis Of The Medicinal Properties Of The Plant," Journal of Pharmaceutical Negative Results, pp. 1595-1600, 2023.

P. Poczai and J. Hyvönen, "On the origin of Solanum nigrum: can networks help?," Molecular biology reports, vol. 38, pp. 1171-1185, 2011.

P. Ganguly, A. K. Gupta, U. K. Majumder, and S. Ghosal, "The chemistry behind the toxicity of black nightshade, Solanum nigrum and the remedy," Pharmacologyonline, vol. 1, pp. 705-723, 2009.

L. J. Schep, R. J. Slaughter, and W. A. Temple, "Contaminant berries in frozen vegetables," The New Zealand Medical Journal (Online), vol. 122, 2009.

C. Bravo, S. Velilla, L. Bautista, and B. Peco, "Effects of great bustard (Otis tarda) gut passage on black nightshade (Solanumnigrum) seed germination," Seed science research, vol. 24, pp. 265-271, 2014.

N. J. Turner and P. von Aderkas, The North American guide to common poisonous plants and mushrooms: Timber Press, 2009.

Y. Wang, L. Xiang, X. Yi, and X. He, "Potential anti-inflammatory steroidal saponins from the berries of Solanum nigrum L.(European Black Nightshade)," Journal of agricultural and food chemistry, vol. 65, pp. 4262-4272, 2017.

X. Chen, X. Dai, Y. Liu, Y. Yang, L. Yuan, X. He, et al., "Solanum nigrum Linn.: an insight into current research on traditional uses, phytochemistry, and pharmacology," Frontiers in Pharmacology, vol. 13, p. 918071, 2022.

L. Xiang, Y. Wang, X. Yi, and X. He, "Steroidal alkaloid glycosides and phenolics from the immature fruits of Solanum nigrum," Fitoterapia, vol. 137, p. 104268, 2019.

A. Campisi, R. Acquaviva, G. Raciti, A. Duro, M. Rizzo, and N. A. Santagati, "Antioxidant activities of Solanum nigrum L. leaf extracts determined in in vitro cellular models," Foods, vol. 8, p. 63, 2019.

A. Jabamalairaj, R. A. Priatama, J. Heo, and S. J. Park, "Medicinal metabolites with common biosynthetic pathways in Solanum nigrum," Plant Biotechnology Reports, vol. 13, pp. 315-327, 2019.

Q. Zhang, D. Liu, Y. Cui, T. Xu, T. Lu, X. Liu, et al., "Bioactivities and chemical profiling comparison and metabolomic variations of polyphenolics and steroidal glycoalkaloids in different parts of Solanum nigrum L," Phytochemical Analysis, vol. 35, pp. 350-368, 2024.

R. A. Shibli, R. W. Tahtamouni, T. S. AlQudah, and B. B. Abu-Iramaileh, "Improving solanine production in in vitro cultures of Solanum nigrum L. using different chemical and physical factors," Journal of Agricultural and Marine Sciences [JAMS], vol. 24, pp. 51-62, 2019.

S. Sabu and C. Kalpana, "Phytochemical contituents andnutrient composition of fresh and cooked Solanum nigrum leaves," Asian J of Multidimensional Res, vol. 7, pp. 231-34, 2018.

M. Musto, "Preliminary report on antifungal activity of a Solanum nigrum extract against five mycotoxin-producing fungi," Emirates Journal of Food and Agriculture, pp. 825-830, 2015.

T. Sabudak, M. Öztürk, and E. Alpay, "New bioflavonoids from Solanum nigrum L. by anticholinesterase and anti-tyrosinase activities-guided fractionation," 2017.

M. Shenbagam and R. Sulthana, "A review: Solanum nigrum and its pharmacological activities," Int J Res App Sci Eng Tech, vol. 10, pp. 916-23, 2022.

A. M. UD-DIN, Z.-U. DIN KHAN, M. Ahmad, M. AKRAM KASHMIRI, S. Yasmin, and H. Mazhar, "Chemotaxonomic significance of flavonoids in the Solanum nigrum complex," Journal of the Chilean Chemical Society, vol. 54, pp. 486-490, 2009.

M. N. Alam, S. Roy, S. M. Anisuzzaman, and M. Rafiquzzaman, "Antioxidant activity of the ethanolic extracts of leaves, stems and fruits of Solanum nigrum," Pharmacogn. Commun, vol. 2, pp. 67-71, 2012.

M. Veerapagu, K. Jeya, A. Sankaranarayanan, and A. Rathika, "In vitro antioxidant properties of methanolic extract of Solanum nigrum L. fruit," The Pharma Innovation, vol. 7, p. 371, 2018.

C. Sivaraj, S. Yamini, A. Yahavi, R. P. Kumar, P. Arumugam, and A. Manimaaran, "Antioxidant, antimicrobial activities and GCMS analysis of fruit extract of Solanum nigrum L," Journal of Pharmacognosy and Phytochemistry, vol. 9, pp. 1114-1121, 2020.


A. N. Artanti and R. Lisnasari, "Uji Aktivitas Antioksidan Ektrak Ethanol Daun Family Solanum Menggunakan Metode Reduksi Radikal Bebas DPPH," Journal of Pharmaceutical Science and Clinical Research, vol. 2, pp. 62-69, 2018.

Y. Wan, S. Luo, J. Chen, X. Xiao, L. Chen, G. Zeng, et al., "Effect of endophyte-infection on growth parameters and Cd-induced phytotoxicity of Cd-hyperaccumulator Solanum nigrum L," Chemosphere, vol. 89, pp. 743-750, 2012.

K. Chester, S. Zahiruddin, A. Ahmad, W. Khan, S. Paliwal, and S. Ahmad, "Bioautography-based identification of antioxidant metabolites of Solanum nigrum L. and exploration its hepatoprotective potential against D-galactosamine-induced hepatic fibrosis in rats," Pharmacognosy Magazine, vol. 15, 2019.

A. H. M. Fayed, A. A. Salama, I. E. Ismaiel, T. A. Attia, and A. Hassan, "Protective Effects Of Solanium Nigrum Methanolic Extract Against Isoniazid/Rifampicin Induced Hepatotoxicity In Rats," Journal of Applied Veterinary Sciences, vol. 4, pp. 52-61, 2019.

A. K. Gupta, P. Ganguly, U. K. Majumder, and S. Ghosal, "Hepatoprotective and antioxidant effects of total extracts and stereoidal saponins of Solanum xanthocarpum and Solanum nigrum in paracetamol induced hepatotoxicity in rats," Pharmacologyonline, vol. 1, pp. 757-768, 2009.

H. Z. Himi, M. M. Rahman, S. A. Hasan, L. R. M. D. Cruze, S. T. Ishraat, and M. M. Chowdhury, "An Evaluation of Hepato-protective Activity of Ethanolic Extract of Solanum nigrum with Varying Doses on CCL4 Induced Hepatic Injured Rat," Asian Journal of Advanced Research and Reports, vol. 18, pp. 75-80, 2024.

S. Patel, N. Gheewala, A. Suthar, and A. Shah, "In-vitro cytotoxicity activity of Solanum nigrum extract against Hela cell line and Vero cell line," Int J Pharm Pharm Sci, vol. 1, pp. 38-46, 2009.

H. A. Khan, N. R. Prasad, S. H. Alrokayan, and A. A. Alghamdi, "Antiproliferative effect of Solanum nigrum L. water extract on breast can-cer cells: potential roles of apoptosis and oxidative stress," Cellular and Molecular Biology, vol. 69, pp. 136-142, 2023.

J.-D. Hsu, S.-H. Kao, C.-C. Tu, Y.-J. Li, and C.-J. Wang, "Solanum nigrum L. extract inhibits 2-acetylaminofluorene-induced hepatocarcinogenesis through overexpression of glutathione S-transferase and antioxidant enzymes," Journal of agricultural and food chemistry, vol. 57, pp. 8628-8634, 2009.

C. Churiyah, S. Ningsih, and F. Firdayani, "The cytotoxic, apoptotic induction, and cell cycle arrest activities of solanum nigrum L. ethanolic extract on MCF-7 human breast cancer cell," Asian Pacific Journal of Cancer Prevention: APJCP, vol. 21, p. 3735, 2020.

M. Huang, M. Liu, B. Li, and K. Li, "Solanine regulates proliferation and apoptosis of gastric cancer cells by targeting miR-140/MACC1 pathway," Chin. J. Clin. Pharmacol, vol. 36, pp. 2440-2443, 2020.

A. C. Öner, F. Yur, and M. N. Fethullah, "Antioxidant and Antihyperlipidemic Effect of Solanum Nigrum Extract in Experimental Diabetes Model," Van Veterinary Journal, vol. 34, pp. 184-188, 2023.

Z. A. B. ZULKIFLI, "ANTIOXIDANT AND ANTIDIABETIC ACTIVITIES OF PROTEINS FROM Moringa oleifera," Universiti Teknologi Malaysia, 2021.


N. Tyagi, A. Sharma, S. K. Verma, and M. S. Sharma, "CNS Acting Potential of Natural Products with Special Reference to Family Solanaceae."

V. D. Mahajan and H. S. Shaikh, "Solanum nigram-A potential medicinal herb," Research Journal of Science and Technology, vol. 15, pp. 27-34, 2023.

C.-H. Peng, J.-J. Cheng, M.-H. Yu, D.-J. Chung, C.-N. Huang, and C.-J. Wang, "Solanum nigrum polyphenols reduce body weight and body fat by affecting adipocyte and lipid metabolism," Food & function, vol. 11, pp. 483-492, 2020.

B. K. Sharma, D. Iyer, and U. Patil, "Bioactivity guided fractionation in experimentally induced hyperlipidemia in rats and characterization of phytoconstituent from Solanum nigrum," Journal of herbs, spices & medicinal plants, vol. 18, pp. 257-267, 2012.

I. A. Imran Ali, W. A. Waqar Ahmed, M. T. Muhammad Tariq, R. A. Rehana Asghar, and M. Hussain, "Therapeutic potential of ethanolic extract of Solanum nigrum for lipofundin-induced hyperlipidemia in rabbits," 2016.

R. Chauhan, K. Ruby, A. Shori, and J. Dwivedi, "Solanum nigrum with dynamic therapeutic role: A review," International Journal of Pharmaceutical Sciences Review and Research, vol. 15, pp. 65-71, 2012.

L. Jithendran and C. Kalpana, "Nutritional potential of Solanum nigrum linn berries grown in home garden," International Journal of Food and Nutritional Sciences, vol. 10, pp. 16-16, 2021.








How to Cite

Overview of the Biochemical Potential of Solanum Nigrum. (2024). University of Thi-Qar Journal of Science, 11(1), 190-196. https://doi.org/10.32792/utq/utjsci/v11i1.1239