Estimation of Hepcidin Role and some Biochemical Parameters in Patients with Beta- thalassemia in Thi-Qar Governorate/ Iraq


  • Alyaa Majid Department of Chemistry, College of Science, University of Thi-Qar, Thi-Qar, 64001, Iraq.
  • Saliha Alyar Department of Chemistry, Faculty of Science, Karatekin University, 18100, Çankırı, Turkey
  • Mohammed Yasir Almusawi Iraqi Ministry of Health



Hepcidin, Ferretin, β-thalassemia, Hemoglobin


The β-thalassemias are a group of recessively inherited genetic disorders that cause varying amounts of hemoglobin production. The study's aim was to look at hepcidin, ferretin, iron, PCV, Hb, ALT, AST, and albumin levels. Serum hepcidin, ferretin, iron, PCV, Hb, ALT, AST, and albumin levels were determined in 55 patients with beta-thalassemia and 55 healthy individuals. The results demonstrated a substantial rise in serum concentrations of ferretin, iron, ALT and AST in the beta-thalassemia group as compared to the control group(p<0.001).  There was also a significant decrease in the concentrations in the serum of hepcidin, packed cell volume, hemoglobin and albumin (p<0.001).  


S. Sardar, E. A. Ali, & M. A. Yassin," Thalassemia and Priapism: A Literature Review of a Rare Association," Cureus, 13, 4, e14335, 2021.

L. T. Swee,"Molecular basis of β thalassemia and potential therapeutic targets," Blood Cells, Molecules, and Diseases, 70, 54-65, 2018.

R.Galanello, & R. Origa,"Beta-thalassemia," Orphanet Journal of Rare Diseases, 5, 1, 1-15, 2010.

A. M. Mohammed, "Serum levels of lipid and lipoproteins in patients with beta- thalassemia in Amara S.Iraq," J.Thi-Qar Sci, 1, 3, 2009.

H. F. Okab, M. B. Saleh, ". Evaluation The Immune Status Of Blood Transfusion-Dependent Thalassemia In Thi-Qar Province/Iraq," Journal of Education for Pure Science- University of Thi-Qar, 9,2, 2019.

I. I. Jabbar, " An enzymatic and biochemical study of patients with beta thalassemia,"Al-Qadisiyah University/College of Science/Department of Biology, 2021.

S. R. Mehdi, & B. A. Al Dahmash," A comparative study of hematological parameters of α and β-thalassemias in a high prevalence zone: Saudi Arabia," Indian Journal of Human Genetics, 17, 3, 207, 2011.

S. A. Sarnaik," Thalassemia and related hemoglobin opathies," The Indian Journal of Pediatrics, 72, 4, 319-324, 2005.

I. G. Hasoon, W. S.Shani, & A. M. Radi," The association of hepcidin with some inflammatory markers in β-thalassemia major patients of Basrah Province," Eur. Asian Journal of BioSciences, 14, 2, 7285-7289, 2020.

W. Wanachiwanawin, P. Luengrojanakul, P. Sirangkapracha, W. Leowattana, & S.Fucharoen,"Prevalence and clinical significance of hepatitis C virus infection in Thai patients with thalassemia," International Journal of Hematology, 78, 4, 374-378, 1003.

E. Nemeth, M. S. Tuttle, J. Powelson, M. B. Vaughn, A. Donovan, D. M. Ward,. & J. Kaplan," Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization, "Science, 306, 5704, 2090-2093, 2004.

N. Elizabetth,"Hepcidin in β-thalassemia. available in PMC 2011 Aug.Published in final edited form as," Ann. N. Y. Acad. Sci, 1202, 31–35, 2010.

S. Fucharoen, &Weatherall, D. J," The hemoglobin E thalassemias," Cold Spring Harbor Perspectives in Medicine, 2, 8, a011734, 2012.

F. Shafique, S. Ali, T. Almansouri, F. Van Eeden, N. Shafi, M. Khalid, & S. Andleeb, "Thalassemia, a human blood disorder," Brazilian Journal of Biology, 83, 1 – 8, 2021.

P. Pootrakul, V. Vongsmasa, P. La-Ongpanich, & P.Wasi,"Serum ferritin levels in thalassemias and the effect of splenectomy," Acta Haematologica, 66, 4, 244-250, 1981.

A. K. Mishra, & A.Tiwari," Iron overload in beta thalassaemia major and intermedia patients," Maedica, 8, 4, 328, 2013.

O. M. Hendy, M. Allam, A. Allam, M. H. Attia, S. El Taher, M. M. Eldin, & A. Ali,"2010 Hepcidin levels and iron status in beta-thalassemia major patients with hepatitis C virus infection," The Egyptian Journal of Immunology, 17, 2, 33-44, 2010

M. Ibrahim, A. Atef, A. Zeitoun, H. El-Hagrasi, & F. M. Attia, " Evaluation of Liver Functions in Beta-thalassemic Patients in Ismailia," Suez Canal University Medical Journal, 14, 1, 16-21, 2011.

K. M. Salama, O. M. Ibrahim, A. M. Kaddah, S. Boseila, L. A. Ismail, & M. M. A. Hamid,"Liver enzymes in children with beta-thalassemia major: correlation with iron overload and viral hepatitis," Open Access Macedonian Journal of Medical Sciences, 3, 2, 287, 2015.

A. W. Nienhuis, &Nathan, D. G." Pathophysiology and clinical manifestations of the β-thalassemias," Cold Spring Harbor Perspectives in Medicine, 2, 12, a011726, 2012.

Z. H. Alhillawi, H. K. Al-Hakeim, S. R. Moustafa, & M. Maes,"Increased zinc and albumin but lowered copper in children with transfusion-dependent thalassemia.,"Journal of Trace Elements in Medicine and Biology, 65, 126713, 2021.








How to Cite

Estimation of Hepcidin Role and some Biochemical Parameters in Patients with Beta- thalassemia in Thi-Qar Governorate/ Iraq. (2024). University of Thi-Qar Journal of Science, 11(1), 88-91.