Physiological Change of Interleukin-1 Alpha (IL-1α) in Iraqi, Thi-Qar Women with Polycystic Ovarian Syndrome

Abstract

Background: A frequent and significant pro-inflammatory cytokine is IL-1α. In healthy cells, the IL-1α precursor is essentially present in almost all cell types, but it becomes a bioactive mediator upon necrotic cell death. IL-1α is also expressed by infiltrating myeloid cells within injured tissues. Aim and Objective: In this review, we focus on the biology of IL-1, its relationship to polycystic ovarian syndrome, and its developing role in the development and maintenance of the inflammatory processes that underlie the pathophysiology of PCOS women. Between the ages of (16 and 43), the 75 female patients enduring polycystic ovary syndrome are compared to the (50) healthy emales in the oversight group. IL- - alpha concentrations were noticeably greater in PCOS women compared to the control group, with p-values between (0.05-0.01)indicating a significant difference. These findings examined a non-significant difference in IL- levels between PCOS women and the control group, according to BMI. The research showed that PCOS women had considerably more IL-1 than women without PCOS in all BMI groups. IL-1-, however, in PCOS women and the Control Group The present findings looked at a non-significant variation in IL-1- concentration between PCOS women and the control group, according to Age. According to Age, the current results investigated at a non-significant difference in the concentration of IL-1- in PCOS women and the control group. When comparable age groups for women with (PCOS) and controls were examined, the results showed a significant rise in PCOS cases at p. value < 0.05.